Results 71 to 80 of about 226,720 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analysis of exponential stability and L1-gain performance of positive switched impulsive systems with all unstable subsystems

Nonlinear Analysis
This article investigates the exponential stability and L1-gain performance of time-varying positive switched impulsive systems even when all modes are unstable.
Xiukun Zhang, Yuangong Sun, Xingao Zhu
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Robust Stability of Switched Interconnected Systems with Switching Uncertainties

Mathematics
This paper investigates the problem of robust stability for a class of switched interconnected systems characterized by unstable modes, time-varying state delays, and switching uncertainties.
Huanbin Xue, Xiaopeng Yang
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Two-Layer Security for Image Encryption: A Switched System Approach

IEEE Access
This paper proposes an image encryption-decryption scheme with two-layer security. In the first layer, an image is encrypted by a switched system, using the concept from control theory.
Uyen L. P. Nguyen, Long Tonthat, Vo-Tan Phuoc, Lap Luat Nguyen   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Fault Detection Based on Interval Observers and Dynamic Event–Triggered Fault–Tolerant Control for Morphing Aircraft

International Journal of Applied Mathematics and Computer Science
In this paper, a fault detection mechanism using interval observers and a robust fault-tolerant control strategy with dynamic event-triggered mechanism are designed for the switched control problem during the transformation process of a morphing aircraft.
Fu Xingjian, Wang Xiaohan
doaj   +1 more source

On Switched Hamiltonan Systems

, 2002
In this paper we study the well-posedness and stability of a class of switched linear passive systems. Instrumental in our approach is the result, also of interest in its own right, that any linear passive input-state-output system with strictly positive storage function can be written as a port-Hamiltonian system.
Gerritsen, K.M., van der Schaft, Abraham Jan, Heemels, W.P.M.H.   +2 more
openaire   +2 more sources