Results 41 to 50 of about 363 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Comparison of boost and LLC converter and active clamp isolated full-bridge boost converter for photovoltaic DC system

open access: yesThe Journal of Engineering, 2019
DC collection network offers an attractive alternative to AC network for photovoltaic, as it avoids the charging current issues and reduces the size and weight. Variable voltage gain DC/DC converters play an important role in DC collection network.
Jiye Liu   +3 more
doaj   +1 more source

Novel capacitance-ratio-independent switched-capacitor digital-analogue convertor

open access: yesElectronics Letters, 1989
A novel switched-capacitor (SC digital-to-analogue (D/A) convertor is presented which exhibits high linearity owing to a capacitance-ratio-independent conversion algorithm. The core of the convertor consists of an SC circuit which processes the digital word, bit-by-bit, by integrating the reference voltage for a number of time slots corresponding to ...
J.C. Vital, J.E. Franca
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

A Wide Input Voltage Range Unidirectional Resonant Switched‐Capacitor Converter for Fuel Cell Applications

open access: yesIET Power Electronics
This paper introduces a full bridge high voltage gain resonant switched capacitor converter (SCC) providing soft switching conditions for all power semiconductors above and below the resonant frequencies.
Sajad Afshar Zarandi   +2 more
doaj   +1 more source

Current-sensorless online ESR monitoring of capacitors in boost converter

open access: yesThe Journal of Engineering, 2019
boost circuit has been widely used in photovoltaic generation system and electrolytic capacitor is one of the most vulnerable components in the circuit.
Shengxue Tang   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Design and comparative evaluation of converter topologies for six-phase switched reluctance motor drives

open access: yesThe Journal of Engineering, 2019
This paper presents a novel converter topology for six-phase switched reluctance motor (SRM) drives, which reduces the number of switches and diodes by half, compared with the conventional asymmetric half-bridge (AHB) converter, and needs no additional ...
Xu Deng, Barrie Mecrow
doaj   +1 more source

SPICE simulation of quasi-resonant zero-current-switching DC-DC convertors

open access: yesElectronics Letters, 1990
A simple, topology-independent method is proposed for simulating the responses of open and closed-loop quasiresonant DC-DC convertors operating in the zero-current-switching mode (ZCS-QRC). The method hinges on the substitution of the resonant network and switch assembly, fundamental in the realisation of such systems, by an equivalent circuit which ...
S. Ben-Yaakov   +3 more
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

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