Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Instantaneous conduction and switching losses in two-level voltage source inverters [PDF]
A mathematical model is derived which allows to compute instantaneously the conduction and switching losses in two-level voltage source inverters (2L-VSIs) regardless of the employed modulation scheme.
Fakharmanesh, Mahdi +2 more
core +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Modulated Model-Free Predictive Control With Minimum Switching Losses for PMSM Drive System
A modulated model-free predictive control with minimum switching losses (MSL-MMFPC) is proposed to improve the steady-state performance and reduce the switching losses for a permanent magnet synchronous motor (PMSM) drive system.
Yuchen Wang +4 more
doaj +1 more source
A Performance Optimized CSTBT with Low Switching Loss
A novel Performance Optimized Carrier Stored Trench Gate Bipolar Transistor (CSTBT) with Low Switching Loss has been proposed. By applying a positive DC voltage to the shield gate, the carrier storage effect is enhanced, the hole blocking capability is improved and the conduction loss is reduced.
Hang Xu +4 more
openaire +3 more sources
A Single-Stage LED Driver Based on ZCDS Class-E Current-Driven Rectifier as a PFC for Street-Lighting Applications [PDF]
This paper presents a light-emitting diode (LED) driver for street-lighting applications that uses a resonant rectifier as a power-factor corrector (PFC).
Chainarin Ekkaravarodome +5 more
core +2 more sources
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Novel ZVS S-TCM Modulation of Three-Phase AC/DC Converters
For three-phase AC-DC power conversion, the widely-used continuous current mode (CCM) modulation scheme results in relatively high semiconductor losses from hard-switching each device during half of the mains cycle.
Michael Haider +7 more
doaj +1 more source

