Results 61 to 70 of about 4,657,044 (399)
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source
Comparative Legilinguistics, 2019 The aim of this paper is to present LEX.CH.IT, a corpus for micro-diachronic linguistic investigations of Swiss normative acts in Italian. Italian has a peculiar position as an official minority translation language within the Swiss institutional system.
Canavese Paolo
doaj +1 more source
BMJ Open, 2017 Background Bloodstream infections are often associated with significant mortality and morbidity. We aimed to investigate changes in the epidemiology of bloodstream infections in Switzerland between 2008 and 2014.
N. Buetti +3 more
semanticscholar +1 more source
LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD : a systematic review and meta-analysis [PDF]
, 2017 Acknowledgments The meta-analysis work was performed by Guruprasad Rao KS and Sharanbasappa Durg of Molecular Connections (P) Ltd, Bangalore, India, under the guidance of the manuscript authors and Novartis Pharma AG (Basel, Switzerland). Medical writing
Altman, Pablo +8 more
core +2 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
A Fragile Field. The Development and Transformation of Science and Technology Studies in Switzerland
Tecnoscienza, 2017 This contribution reconstructs the history of Science and Technology Studies in Switzerland. With a focus on the institutional aspects of the field’s emergence, it traces early initiatives to foster social research on science and technology, then ...
Regula Valérie Burri, Martina Merz
doaj +1 more source
Performing investigative identities: How print journalists establish authority through their texts
Studies in Communication Sciences, 2023 Faced with an increasingly challenging environment, journalists and news organizations are looking to investigative journalism as a symbolic resource to assert their professionalism.
Lena Wuergler, Annik Dubied
doaj +1 more source
Metallized Film Capacitor Lifetime Evaluation and Failure Mode Analysis [PDF]
CERN Yellow Report CERN-2015-003, pp.45-56, 2016 One of the main concerns for power electronic engineers regarding capacitors is to predict their remaining lifetime in order to anticipate costly failures or system unavailability. This may be achieved using a Weibull statistical law combined with acceleration factors for the temperature, the voltage, and the humidity.
arxiv +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Natural hazard fatalities in Switzerland from 1946 to 2015
, 2016 . A database of fatalities caused by natural hazard processes in Switzerland was compiled for the period between 1946 and 2015. Using information from the Swiss flood and landslide damage database and the Swiss destructive avalanche database, the data ...
A. Badoux +3 more
semanticscholar +1 more source