Results 61 to 70 of about 3,394,183 (296)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

The KIT:c.376G>A variant in German and Swiss alpacas (Vicugna pacos) with different coat colors [PDF]

open access: hybrid, 2022
Kirsty Tan   +6 more
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

A Fragile Field. The Development and Transformation of Science and Technology Studies in Switzerland

open access: yesTecnoscienza, 2017
This contribution reconstructs the history of Science and Technology Studies in Switzerland. With a focus on the institutional aspects of the field’s emergence, it traces early initiatives to foster social research on science and technology, then ...
Regula Valérie Burri, Martina Merz
doaj   +1 more source

On the link between cold fronts and hail in Switzerland

open access: yes, 2016
Hail is the costliest atmospheric hazard in Switzerland, causing substantial damage to agriculture, cars and buildings every year. In this study, a 12‐year statistic of objectively identified cold fronts and a radar‐based hail statistic are combined to ...
S. Schemm   +4 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

LEX.CH.IT: A Corpus for Micro-Diachronic Linguistic Investigations of Swiss Normative Acts in Italian

open access: yesComparative Legilinguistics, 2019
The aim of this paper is to present LEX.CH.IT, a corpus for micro-diachronic linguistic investigations of Swiss normative acts in Italian. Italian has a peculiar position as an official minority translation language within the Swiss institutional system.
Canavese Paolo
doaj   +1 more source

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