Results 71 to 80 of about 3,394,183 (296)

Early childhood caries in Switzerland: a marker of social inequalities

open access: yesBMC Oral Health, 2015
BackgroundEarly childhood caries (ECC) is a marker of social inequalities worldwide because disadvantaged children are more likely to develop caries than their peers.
Stéphanie Baggio   +4 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Journalists in Switzerland: Structures and attitudes revisited

open access: yesStudies in Communication Sciences, 2018
It is often stated that journalism and the media are going through some fundamental changes. In this article, we present a description of the journalists in Switzerland, based on a nation-wide survey conducted in 2015.
Filip Dingerkus   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Monthly RUSLE soil erosion risk of Swiss grasslands

open access: yesJournal of Maps, 2019
This study presents the first mapping of soil erosion risk modelling based on the Revised Universal Soil Loss Equation (RUSLE) at a sub-annual (monthly) temporal resolution and national scale (100 m spatial resolution).
Simon Schmidt   +2 more
doaj   +1 more source

Partizipation im digitalen Staat: Möglichkeiten und Bedeutung digitaler und analoger Partizipationsinstrumente im Vergleich

open access: yesYearbook of Swiss Administrative Sciences, 2020
The ongoing digitization gives rise to the possibility for administrations to offer citizen participation digitally by using so-called e-participation offerings.
Damaris Fischer   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

From the Object to the Mould: Is there a Connection between Microstructure of a Cast Bronze Object and its Mould Material Used?

open access: yesEXARC Journal, 2012
The question studied within the framework of the Wilhelminaoord Workshop was: In which way the mould material does influence the cast structure of a bronze object?
Emanuela Jochum Zimmerman   +2 more
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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