Results 31 to 40 of about 6,053 (224)
Adrenal adrenoceptors in heart failure
Frontiers in Physiology, 2014 Heart failure (HF) is a chronic clinical syndrome characterized by the reduction in left ventricular (LV) function and it represents one of the most important causes of morbidity and mortality worldwide.
Claudio ede Lucia +12 more
doaj +1 more source
Direct Vasodilators and Sympatholytic Agents
Journal of Cardiovascular Pharmacology and Therapeutics, 2015 Direct vasodilators and sympatholytic agents were some of the first antihypertensive medications discovered and utilized in the past century. However, side effect profiles and the advent of newer antihypertensive drug classes have reduced the use of these agents in recent decades.
Meghan N, McComb +2 more
openaire +2 more sources
Вестник анестезиологии и реаниматологии, 2018 Dexmedetomidine is a high-selective α2-agonist, which is used as an anesthetic component, and it is expected to induce polyuria. Initially, it was mainly used for sedation in emergency wards, and further this medicine got widespread use in anesthesiology.
A. V. Solenkova +6 more
doaj +1 more source
Blood pressure changes after renal denervation at 10 European expert centers [PDF]
, 2013 We did a subject-level meta-analysis of the changes (Δ) in blood pressure (BP) observed 3 and 6 months after renal denervation (RDN) at 10 European centers. Recruited patients (n=109; 46.8% women; mean age 58.2 years) had essential hypertension confirmed
Adiyaman, A +26 more
core +3 more sources
The place of modern α-2-agonists in the intraoperative sedation of trauma / orthopedic patients
Perioperative Medicine, 2020 Modern traumatological operations have a number of features: duration, a large pool of age-related patients with low functional reserves, forced position of the body, operations are often under regional anesthesia with a conserved consciousness, which ...
A Domoratskiy +5 more
doaj +1 more source
Micro-RNA family that modulates fibrosis and uses thereof [PDF]
, 2017 The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
core +1 more source
Endogenous Circulating Sympatholytic Factor in Orthostatic Intolerance [PDF]
Hypertension, 2000 Abstract—Sympathotonic orthostatic hypotension (SOH) is an idiopathic syndrome characterized by tachycardia, hypotension, elevated plasma norepinephrine, and symptoms of orthostatic intolerance provoked by assumption of an upright posture. We studied a woman with severe progressive SOH with blood pressure unresponsive to the pressor effects of α1 ...
R E, Shapiro +6 more
openaire +2 more sources
Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation [PDF]
, 2019 Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation.
Allegaert, Karel +8 more
core +5 more sources
Micro-RNAS that control myosin expression and myofiber identity [PDF]
, 2015 The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber
Olson, Eric N., van Rooij, Eva
core +1 more source
Elevated blood pressure, heart rate and body temperature in mice lacking the XL alpha s protein of the Gnas locus is due to increased sympathetic tone [PDF]
, 2013 NEW FINDINGS: What is the central question of this study? Previously, we showed that Gnasxl knock-out mice are lean and hypermetabolic, with increased sympathetic stimulation of adipose tissue.
Antonius Plagge +5 more
core +1 more source