Results 21 to 30 of about 1,690 (172)

Next Step in Chronic Kidney Disease Therapy

Počki, 2016
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are the basis of renoprotection therapy in chronic kidney disease. Parallel to decrease of glomerular filtration rate, there is an increase in the activity of the sympathetic nervous ...
D.D. Ivanov
doaj   +1 more source

Tumor necrosis factor, interleukin-1 and interleukin-8 mediate the nociceptive activity of the supernatant of LPS-stimulated macrophages

Mediators of Inflammation, 1997
It has been suggested that the supernatant of LPSstimulated macrophages (macrophage nociceptive factor, MNF) promotes nociception in mice. Intraperitoneal administration of MNF induced dose-related writhing, which reached a plateau between 18 and 26 min ...
S. M. Thomazzi, R. A. Ribeiro, D. I. Campos, F. Q. Cunha, S. H. Ferreira   +4 more
doaj   +1 more source

N‐terminal pro‐brain natriuretic peptide and cardiorenal outcome in patients with anaemia in chronic kidney disease

ESC Heart Failure, Volume 12, Issue 2, Page 848-858, April 2025.
Abstract Aims Blood levels of N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) may be modified by low renal clearance and anaemia. The aim of this study was to investigate the impact of the blood NT‐proBNP level on cardiovascular and renal outcomes in patients with these two manifestations.
Hiroshi Nishi, Masaomi Nangaku, Tadashi Sofue, Tatsuo Kagimura, Ichiei Narita   +4 more
wiley   +1 more source

Interventions to prevent postoperative neurocognitive complications: an umbrella review of meta‐analyses of randomised controlled trials

Anaesthesia, EarlyView.
Summary Introduction The certainty of the effectiveness of interventions to manage postoperative neurocognitive complications remains unclear. The objective of this umbrella review was to synthesise and evaluate the evidence for interventions aimed at reducing the incidence of peri‐operative neurocognitive complications.
Filippo D'Amico, Stefano Turi, Marco Manazza, Giuliana Lo Bianco, Giacomo Monti, Alberto Zangrillo, Giovanni Landoni, Luigi Beretta   +7 more
wiley   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Increases in skin perfusion and blood oxygen in the non‐exercising human limbs during exercise in the heat: Implications for control of circulation

Experimental Physiology, EarlyView.
Abstract Blood flow in the inactive limb tissues and skin is widely thought to decline during incremental exercise to exhaustion due to augmented sympathoadrenal vasoconstrictor activity, but direct evidence to support this view is lacking. Here, we investigated the inactive‐forearm haemodynamic (Q̇forearm${\dot{Q}}_{\mathrm{forearm}}$) and oxygenation
Steven J. Trangmar, José González‐Alonso   +1 more
wiley   +1 more source

Dexmedetomidine in cardiac surgery: Emphasis on interleukin-18 signaling pathway [PDF]

Journal of Clinical and Basic Research
Background: Dexmedetomidine (Dex), a non-opioid anesthetic and highly selective alpha2 (α2) adrenergic receptor agonist, exerts beneficial effects by mitigating inflammation and myocardial injury during cardiac surgery.
Bassim Mohammed Jabbar Hatemi, Ayesheh Enayati, Ali Movafegh, Ali Jabbari   +3 more
doaj  

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, EarlyView.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

Effects of Dexmedetomidine on the Behavioral Outcomes in Streptozotocin‐Induced Alzheimer's Disease Rats

Brain and Behavior, Volume 16, Issue 1, January 2026.
Dexmedetomidine at 25 µg/kg effectively reverses working and spatial memory deficits in a streptozotocin (STZ)‐induced rat model of Alzheimer's disease, restoring Y‐maze alternation and Morris Water Maze performance. Higher doses show no clear benefit, highlighting Dex‐25 as a promising neuroprotective candidate.
Mina Mohasel‐Roodi, Masoumeh Nozari, Ali Shamsara, Mohsen Basiri, Vida Mirzaie, Masoumeh Baghalishahi   +5 more
wiley   +1 more source

Comparison of Total Intravenous Anesthesia Versus Volatile Anesthesia on Arrhythmia Inducibility and Clinical Outcomes During Catheter Ablation for Ventricular Tachycardia

Journal of Arrhythmia, Volume 41, Issue 6, December 2025.
This study has identified that the maintenance of general anesthesia with TIVA as opposed to volatile anesthesia is associated with increased inducibility of ventricular tachycardia during catheter ablation procedures. 84.5% of TIVA patients were inducible compared to only 15.5%.s ABSTRACT Introduction Catheter ablation is highly efficacious for the ...
Jason Hui, Samual Turnbull, Ashwin Bhaskaran, Saurabh Kumar, Stefan Dieleman   +4 more
wiley   +1 more source