Characterization of New Polyol/H+ Symporters in Debaryomyces hansenii [PDF]
PLoS ONE, 2014 Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through ...
Catarina Prista
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Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
Nature Communications, 2018 Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to ...
Hyunil Jo +2 more
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Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters [PDF]
Membranes, 2023 The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes ...
Stephanie Sauve +3 more
doaj +2 more sources
Overexpression of the HcPT1.1 transporter in Hebeloma cylindrosporum alters the phosphorus accumulation of Pinus pinaster and the distribution of HcPT2 in ectomycorrhizae [PDF]
Frontiers in Plant Science, 2023 Ectomycorrhizal (ECM) fungi are associated with the roots of woody plants in temperate and boreal forests and help them to acquire water and nutrients, particularly phosphorus (P).
Laurie Amenc +5 more
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Journal of Chemical Physics, 2022 Successful functioning of biological cells relies on efficient translocation of different materials across cellular membranes. An important part of this transportation system is membrane channels that are known as antiporters and symporters. They exploit
S Kuroyanagi +2 more
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Functional Roles of the Conserved Amino Acid Sequence Motif C, the Antiporter Motif, in Membrane Transporters of the Major Facilitator Superfamily [PDF]
Biology, 2023 The biological membrane surrounding all living cells forms a hydrophobic barrier to the passage of biologically important molecules. Integral membrane proteins called transporters circumvent the cellular barrier and transport molecules across the cell ...
Manuel F. Varela +4 more
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The joint action of yeast eisosomes and membraneless organelles in response to ethanol stress [PDF]
HeliyonElevated ethanol concentrations in yeast affect the plasma membrane. The plasma membrane in yeast has many lipid-protein complexes, such as Pma1 (MCP), Can1 (MCC), and the eisosome complex.
Camila Moreira Pinto +7 more
doaj +2 more sources
Functional identification and characterization of sodium binding sites in Na symporters
Proceedings of the National Academy of Sciences of the United States of America, 2013 Significance Symporters or cotransporters are proteins that use sodium electrochemical potential gradients to drive sugars, amino acids, anions, and neurotransmitters into cells. Progress in structural biology has provided important clues about substrate
Ernest M Wright
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Chloride binding site of neurotransmitter sodium symporters
Proceedings of the National Academy of Sciences of the United States of America, 2013 Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are chloride-independent but contain an acidic residue ...
Matthias Quick +2 more
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Insights into the mechanism and pharmacology of neurotransmitter sodium symporters
Current Opinion in Structural Biology, 2019 Vikas Navratna, Eric Gouaux
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