Inhibitor binding mode and allosteric regulation of Na + -glucose symporters [PDF]
Nature Communications, 2018 Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to ...
Paola Bisignano +9 more
doaj +7 more sources
Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters [PDF]
Membranes, 2023 The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes ...
Stephanie Sauve +3 more
doaj +2 more sources
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter [PDF]
Nature Communications, 2016 The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:
Christian B. Billesbølle +7 more
doaj +2 more sources
Functional Roles of the Conserved Amino Acid Sequence Motif C, the Antiporter Motif, in Membrane Transporters of the Major Facilitator Superfamily [PDF]
Biology, 2023 The biological membrane surrounding all living cells forms a hydrophobic barrier to the passage of biologically important molecules. Integral membrane proteins called transporters circumvent the cellular barrier and transport molecules across the cell ...
Manuel F. Varela +4 more
doaj +2 more sources
Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters [PDF]
FEBS Open BioThe cation‐chloride cotransporter (CCC) family includes ion symporters that cotransport monovalent cations and Cl−, playing a crucial role in controlling cytoplasmic ion content.
Satoshi Fudo +4 more
doaj +2 more sources
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling [PDF]
eLifeMetabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation.
Joseph Hanna +14 more
doaj +2 more sources
The joint action of yeast eisosomes and membraneless organelles in response to ethanol stress [PDF]
HeliyonElevated ethanol concentrations in yeast affect the plasma membrane. The plasma membrane in yeast has many lipid-protein complexes, such as Pma1 (MCP), Can1 (MCC), and the eisosome complex.
Camila Moreira Pinto +7 more
doaj +2 more sources
Mosaic Evolution of Membrane Transporters in Galdieriales [PDF]
PlantsMembrane transporters are vital for solute movement and localisation across cellular compartments, particularly in extremophilic organisms such as Galdieriales.
Claudia Ciniglia +6 more
doaj +2 more sources
Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters. [PDF]
J Biol ChemXiao Q +5 more
europepmc +2 more sources
pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases. [PDF]
PLoS ONE, 2016 Bacterial sugar symporters in the Major Facilitator Superfamily (MFS) use the H+ (and in a few cases Na+) electrochemical gradients to achieve active transport of sugar into the cell.
Andre Bazzone +3 more
doaj +1 more source