Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters [PDF]
Membranes, 2023 The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes ...
Stephanie Sauve +3 more
doaj +5 more sources
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters [PDF]
Nature Communications, 2018 Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to ...
Hyunil Jo +2 more
exaly +9 more sources
Functional Roles of the Conserved Amino Acid Sequence Motif C, the Antiporter Motif, in Membrane Transporters of the Major Facilitator Superfamily [PDF]
Biology, 2023 The biological membrane surrounding all living cells forms a hydrophobic barrier to the passage of biologically important molecules. Integral membrane proteins called transporters circumvent the cellular barrier and transport molecules across the cell ...
Manuel F. Varela +4 more
doaj +2 more sources
Overexpression of the HcPT1.1 transporter in Hebeloma cylindrosporum alters the phosphorus accumulation of Pinus pinaster and the distribution of HcPT2 in ectomycorrhizae [PDF]
Frontiers in Plant Science, 2023 Ectomycorrhizal (ECM) fungi are associated with the roots of woody plants in temperate and boreal forests and help them to acquire water and nutrients, particularly phosphorus (P).
Laurie Amenc +5 more
doaj +2 more sources
Characterization of New Polyol/H+ Symporters in Debaryomyces hansenii [PDF]
PLoS ONE, 2014 Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through ...
Catarina Prista
exaly +2 more sources
Sodium Iodide Symporter (NIS) and Thyroid [PDF]
HORMONES, 2002 idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine Spitzweg, John C. Morris
openalex +3 more sources
The joint action of yeast eisosomes and membraneless organelles in response to ethanol stress [PDF]
HeliyonElevated ethanol concentrations in yeast affect the plasma membrane. The plasma membrane in yeast has many lipid-protein complexes, such as Pma1 (MCP), Can1 (MCC), and the eisosome complex.
Camila Moreira Pinto +7 more
doaj +2 more sources
Chloride binding site of neurotransmitter sodium symporters [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2013 Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are chloride-independent but contain an acidic residue (Glu290 in LeuT) at a site where eukaryotic NSSs have a serine.
Matthias Quick +2 more
exaly +5 more sources
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters [PDF]
Nature Structural and Molecular Biology, 2014 Neurotransmitter/sodium symporters (NSSs) terminate synaptic signal transmission by Na+-dependent reuptake of released neurotransmitters. Key conformational states have been reported for the bacterial homolog LeuT and an inhibitor-bound Drosophila dopamine transporter. However, a coherent mechanism of Na+-driven transport has not been described.
Joseph A Lyons +2 more
exaly +5 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum. [PDF]
FEBS LettIn Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Karapanagioti F +3 more
europepmc +2 more sources