Inhibitor binding mode and allosteric regulation of Na + -glucose symporters [PDF]
Nature Communications, 2018 Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to ...
Paola Bisignano +9 more
doaj +7 more sources
Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters [PDF]
FEBS Open BioThe cation‐chloride cotransporter (CCC) family includes ion symporters that cotransport monovalent cations and Cl−, playing a crucial role in controlling cytoplasmic ion content.
Satoshi Fudo +4 more
doaj +2 more sources
Allosteric effects of the coupling cation in melibiose transporter MelB [PDF]
eLifeThe major facilitator superfamily (MFS) transporters play significant roles in human health and disease. Salmonella enterica serovar Typhimurium melibiose permease (MelBSt) catalyzes the symport of galactosides with Na+, H+, or Li+ and is a prototype of ...
Parameswaran Hariharan +5 more
doaj +2 more sources
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling [PDF]
eLifeMetabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation.
Joseph Hanna +14 more
doaj +2 more sources
Mosaic Evolution of Membrane Transporters in Galdieriales [PDF]
PlantsMembrane transporters are vital for solute movement and localisation across cellular compartments, particularly in extremophilic organisms such as Galdieriales.
Claudia Ciniglia +6 more
doaj +2 more sources
Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters
Membranes, 2023 The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes ...
Stephanie Sauve +3 more
doaj +1 more source
pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases. [PDF]
PLoS ONE, 2016 Bacterial sugar symporters in the Major Facilitator Superfamily (MFS) use the H+ (and in a few cases Na+) electrochemical gradients to achieve active transport of sugar into the cell.
Andre Bazzone +3 more
doaj +1 more source
Frontiers in Plant Science, 2023 Ectomycorrhizal (ECM) fungi are associated with the roots of woody plants in temperate and boreal forests and help them to acquire water and nutrients, particularly phosphorus (P).
Laurie Amenc +5 more
doaj +1 more source
Characterization of new polyol/H+ symporters in Debaryomyces hansenii. [PDF]
PLoS ONE, 2014 Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through ...
Iliana Pereira +4 more
doaj +1 more source
Mechanism of substrate binding and transport in BASS transporters
eLife, 2023 The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants.
Patrick Becker +5 more
doaj +1 more source