Results 11 to 20 of about 12,546 (277)
pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases. [PDF]
PLoS ONE, 2016 Bacterial sugar symporters in the Major Facilitator Superfamily (MFS) use the H+ (and in a few cases Na+) electrochemical gradients to achieve active transport of sugar into the cell.
Andre Bazzone +3 more
doaj +1 more source
Mechanism of substrate binding and transport in BASS transporters
eLife, 2023 The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants.
Patrick Becker +5 more
doaj +1 more source
Gitelman syndrome combined with complete growth hormone deficiency [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2013 Gitelman syndrome is a rare autosomal recessive hereditary salt-losing tubulopathy, that manifests as hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria.
Se Ra Min +4 more
doaj +1 more source
Glycine Transporter 2: Mechanism and Allosteric Modulation
Frontiers in Molecular Biosciences, 2021 Neurotransmitter sodium symporters (NSS) are a subfamily of SLC6 transporters responsible for regulating neurotransmitter signalling. They are a major target for psychoactive substances including antidepressants and drugs of abuse, prompting substantial ...
Zachary J. Frangos +2 more
doaj +1 more source
Equilibrium Properties of E. coli Lactose Permease Symport -- A Random-walk Model Approach [PDF]
, 2021 The symport of lactose and H+ is an important physiological process in E. coli, for it is closely related to cellular energy supply. In this paper, the symport of H+ and lactose by E. coli LacY protein is computationally simulated using a newly proposed cotransport model that takes the "leakage" phenomenon (uncoupled sugar translocation) into account ...
arxiv +1 more source
Journal of Fungi, 2021 The three families of yeast plasma membrane potassium influx transporters are represented in Candida albicans: Trk, Acu, and Hak proteins. Hak transporters work as K+-H+ symporters, and the genes coding for Hak proteins are transcriptionally activated ...
Francisco J. Ruiz-Castilla +3 more
doaj +1 more source
Nature Communications, 2020 Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation
Kamil Gotfryd +14 more
doaj +1 more source
Anion Selectivity by the Sodium Iodide Symporter [PDF]
Endocrinology, 2003 Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline +6 more
openaire +2 more sources
A chemiosmotic mechanism of symport [PDF]
Proceedings of the National Academy of Sciences, 2015 Lactose permease (LacY), a paradigm for the largest family of membrane transport proteins, catalyzes the coupled translocation of a galactoside and an H + across the Escherichia coli membrane (galactoside/H + symport).
openaire +5 more sources
The Role of Mfsd2a in Nervous System Diseases
Frontiers in Neuroscience, 2021 Major facilitator superfamily (MFS) is the maximum and most diversified membrane transporter, acting as uniporters, symporters and antiporters. MFS is considered to have a good development potential in the transport of drugs for the treatment of brain ...
Bei Huang +3 more
doaj +1 more source