Inhibitor binding mode and allosteric regulation of Na + -glucose symporters [PDF]
Nature Communications, 2018 Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to ...
Paola Bisignano +9 more
doaj +10 more sources
Characterization of new polyol/H+ symporters in Debaryomyces hansenii. [PDF]
PLoS ONE, 2014 Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through ...
Iliana Pereira +4 more
doaj +4 more sources
Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters. [PDF]
Membranes (Basel), 2023 The major facilitator superfamily (MFS) of transporters consists of three classes of membrane transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS transporters are believed to undergo similar conformational changes ...
Sauve S +3 more
europepmc +2 more sources
Journal of Chemical Physics, 2022 Successful functioning of biological cells relies on efficient translocation of different materials across cellular membranes. An important part of this transportation system is membrane channels that are known as antiporters and symporters. They exploit
Alexander Berlaga, A. Kolomeisky
semanticscholar +3 more sources
Overexpression of the HcPT1.1 transporter in Hebeloma cylindrosporum alters the phosphorus accumulation of Pinus pinaster and the distribution of HcPT2 in ectomycorrhizae. [PDF]
Front Plant Sci, 2023 Ectomycorrhizal (ECM) fungi are associated with the roots of woody plants in temperate and boreal forests and help them to acquire water and nutrients, particularly phosphorus (P).
Amenc L +5 more
europepmc +2 more sources
Functional Roles of the Conserved Amino Acid Sequence Motif C, the Antiporter Motif, in Membrane Transporters of the Major Facilitator Superfamily. [PDF]
Biology (Basel), 2023 The biological membrane surrounding all living cells forms a hydrophobic barrier to the passage of biologically important molecules. Integral membrane proteins called transporters circumvent the cellular barrier and transport molecules across the cell ...
Varela MF +4 more
europepmc +2 more sources
Chloride binding site of neurotransmitter sodium symporters [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2013 Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are chloride-independent but contain an acidic residue (Glu290 in LeuT) at a site where eukaryotic NSSs have a serine.
A. K. Kantcheva +7 more
semanticscholar +7 more sources
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters [PDF]
Nature Structural and Molecular Biology, 2014 Neurotransmitter/sodium symporters (NSSs) terminate synaptic signal transmission by Na+-dependent reuptake of released neurotransmitters. Key conformational states have been reported for the bacterial homolog LeuT and an inhibitor-bound Drosophila dopamine transporter. However, a coherent mechanism of Na+-driven transport has not been described.
L. Malinauskaite +6 more
semanticscholar +7 more sources
Mechanism of chloride interaction with neurotransmitter:sodium symporters
Nature, 2007 Neurotransmitter:sodium symporters (NSS) have a critical role in regulating neurotransmission and are targets for psychostimulants, anti-depressants and other drugs. Whereas the non-homologous glutamate transporters mediate chloride conductance, in the eukaryotic NSS chloride is transported together with the neurotransmitter.
Elia Zomot +5 more
semanticscholar +6 more sources
Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters
The Journal of Physical Chemistry B, 2017 Dimerization is a common feature among the members of the neurotransmitter:sodium symporter (NSS) family of membrane proteins. Yet, the effect of dimerization on the mechanism of action of NSS members is not fully understood.
Mert Gur +3 more
semanticscholar +5 more sources