Results 31 to 40 of about 13,066 (249)

Two glycerol uptake systems contribute to the high osmotolerance of Zygosaccharomyces rouxii [PDF]

, 2015
The accumulation of glycerol is essential for yeast viability upon hyperosmotic stress. Here we show that the osmotolerant yeast Zygosaccharomyces rouxii has two genes, ZrSTL1 and ZrSTL2, encoding transporters mediating the active uptake of glycerol in ...
Ahmadpour, Albertyn, Ansell, Banuelos, Brewster, Brown, Bubnova, Cherry, Czabany, Dakal, Duskova, Edgley, Emmerich, Ferreira, Ferreira, Fleet, Guldener, Hoffman, Hohmann, Inglis, Iwaki, Iwaki, Izawa, Izawa, Kayingo, Kinclova-Zimmermannova, Kinclova-Zimmermannova, Klasson, Kurtzman, Lages, Lages, Lages, Lages, Larsson, Leandro, Leandro, Leandro, Liu, Loureiro-Dias, Lucas, Maresova, Maresova, Martorell, Miesenbock, Nelissen, Neves, Onishi, Orij, Ozcan, Pahlman, Palma, Pereira, Perfect, Pribylova, Pribylova, Pribylova, Pribylova, Proft, Quain, Rep, Roberts, Saito, Serrano, Sherman, Silva-Garca, Silva-Graca, Solieri, Stribny, Tamas, Tang, Vandijken, Yamanishi, Yancey, Yancey, Zhao, Zyl, Zyl, Zyl   +77 more
core   +1 more source

Sodium-Assisted Formation of Binding and Traverse Conformations of the Substrate in a Neurotransmitter Sodium Symporter Model [PDF]

, 2014
Therapeutics designed to increase synaptic neurotransmitter levels by inhibiting neurotransmitter sodium sym- porters (NSSs) classify a strategic approach to treat brain disorders such as depression or epilepsy, however, the critical elementary steps ...
Bencsura, Ákos, Héja, László, Kardos, Julianna, Magyar, Csaba, Simon, Ágnes   +4 more
core   +1 more source

A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state

Nature Communications, 2016
Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and show ...
Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning, Poul Nissen   +11 more
doaj   +1 more source

Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria

Biomolecules, 2020
To function as a metabolic hub, plant mitochondria have to exchange a wide variety of metabolic intermediates as well as inorganic ions with the cytosol.
Ian Max Møller, R. Shyama Prasad Rao, Yuexu Jiang, Jay J. Thelen, Dong Xu   +4 more
doaj   +1 more source

Modeling of SGLT1 in Reconstituted Systems Reveals Apparent Ion-Dependencies of Glucose Uptake and Strengthens the Notion of Water-Permeable Apo States

Frontiers in Physiology, 2022
The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions to ...
Thomas Barta, Walter Sandtner, Johann Wachlmayr, Christof Hannesschlaeger, Andrea Ebert, Armin Speletz, Andreas Horner   +6 more
doaj   +1 more source

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

eLife, 2017
The Neurotransmitter:Sodium Symporters (NSSs) represent an important class of proteins mediating sodium-dependent uptake of neurotransmitters from the extracellular space.
Simon Erlendsson, Kamil Gotfryd, Flemming Hofmann Larsen, Jonas Sigurd Mortensen, Michel-Andreas Geiger, Barth-Jan van Rossum, Hartmut Oschkinat, Ulrik Gether, Kaare Teilum, Claus J Loland   +9 more
doaj   +1 more source

The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

eLife, 2018
The yeast Target of Rapamycin Complex 1 (TORC1) plays a central role in controlling growth. How amino acids and other nutrients stimulate its activity via the Rag/Gtr GTPases remains poorly understood.
Elie Saliba, Minoas Evangelinos, Christos Gournas, Florent Corrillon, Isabelle Georis, Bruno André   +5 more
doaj   +1 more source

Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment [PDF]

, 2013
The capability of osmoadaptation is a prerequisite of organisms that live in an environment with changing salinities. Halobacillus halophilus is a moderately halophilic bacterium that grows between 0.4 and 3 M NaCl by accumulating both chloride and ...
Hänelt, Inga, Müller, Volker
core   +2 more sources

Glucose Transport in the Extremely Thermoacidophilic Sulfolobus solfataricus Involves a High-Affinity Membrane-Integrated Binding Protein [PDF]

, 1999
The archaeon Sulfolobus solfataricus grows optimally at 80°C and pH 2.5 to 3.5 on carbon sources such as yeast extracts, tryptone, and various sugars. Cells rapidly accumulate glucose.
Albers, Sonja-V., Charlebois, Robert L., Driessen, Arnold J.M., Elferink, Marieke G.L., Konings, Wil N., Sensen, Christoph W.   +5 more
core   +7 more sources

Metabolic Profiles of Carbohydrates in Streptococcus thermophilus During pH-Controlled Batch Fermentation

Frontiers in Microbiology, 2020
Revealing the metabolic profiles of carbohydrates with their regulatory genes and metabolites is conducive to understanding their mechanism of utilization in Streptococcus thermophilus MN-ZLW-002 during pH-controlled batch fermentation.
Gefei Liu, Yali Qiao, Yanjiao Zhang, Cong Leng, Hongyu Chen, Jiahui Sun, Xuejing Fan, Aili Li, Zhen Feng   +8 more
doaj   +1 more source