Results 31 to 40 of about 12,546 (277)
Frontiers in Physiology, 2022 The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions to ...
Thomas Barta +6 more
doaj +1 more source
Nature Communications, 2018 Neurotransmitter:sodium symporters (NSS) modulate the duration and magnitude of signaling via the sodium-coupled reuptake of neurotransmitters. Here the authors describe quantitative single molecule imaging of ligand-induced, functional dynamics of both ...
Daniel S. Terry +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in
Rong Zhu +6 more
doaj +1 more source
Monosaccharide transporters in plants: structure, function and physiology [PDF]
, 2000 Monosaccharide transport across the plant plasma membrane plays an important role both in lower and higher plants. Algae can switch between phototrophic and heterotrophic growth and utilize organic compounds, such as monosaccharides as additional or sole
Büttner, Michael, Sauer, Norbert
core +1 more source
Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]
, 2015 Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F +64 more
core +2 more sources
A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state
Nature Communications, 2016 Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and show ...
Lina Malinauskaite +11 more
doaj +1 more source
Two glycerol uptake systems contribute to the high osmotolerance of Zygosaccharomyces rouxii [PDF]
, 2015 The accumulation of glycerol is essential for yeast viability upon hyperosmotic stress. Here we show that the osmotolerant yeast Zygosaccharomyces rouxii has two genes, ZrSTL1 and ZrSTL2, encoding transporters mediating the active uptake of glycerol in ...
Ahmadpour +77 more
core +1 more source
Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters
The Journal of Physical Chemistry B, 2017 Dimerization is a common feature among the members of the neurotransmitter:sodium symporter (NSS) family of membrane proteins. Yet, the effect of dimerization on the mechanism of action of NSS members is not fully understood. In this study, we examined the collective dynamics of two members of the family, leucine transporter (LeuT) and dopamine ...
Mert Gur +3 more
openaire +4 more sources
Frontiers in Microbiology, 2020 Revealing the metabolic profiles of carbohydrates with their regulatory genes and metabolites is conducive to understanding their mechanism of utilization in Streptococcus thermophilus MN-ZLW-002 during pH-controlled batch fermentation.
Gefei Liu +8 more
doaj +1 more source
Gating Topology of the Proton-Coupled Oligopeptide Symporters [PDF]
Structure, 2015 Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS fold facilitates transport through rearrangement of their two six-helix bundles around a central ligand binding site; how this is achieved, however, is poorly understood.
Jane Kwok +10 more
openaire +5 more sources