Results 71 to 80 of about 11,101 (204)
Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley +1 more source
Nuclear medicine in endocrine tumours [PDF]
C
Peremans, Kathelijne +1 more
core +2 more sources
The Downregulation of the Expression of CD147 by Tumor Suppressor REIC/Dkk-3, and Its Implication in Human Prostate Cancer Cell Growth Inhibition [PDF]
The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy.
Ariyoshi, Yuichi +9 more
core +1 more source
We introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Dijana Pavlović Saftić +2 more
wiley +1 more source
Re-annotation of the genome sequence of Helicobacter pylori 26695 [PDF]
Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastriculcers, and gastric cancer. The genome of H. pylori 26695 has been previously sequenced and annotated.
Correia, Daniela M. +3 more
core +1 more source
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich +11 more
wiley +1 more source
Eukaryotic transporters for hydroxyderivatives of benzoic acid
Several yeast species catabolize hydroxyderivatives of benzoic acid. However, the nature of carriers responsible for transport of these compounds across the plasma membrane is currently unknown.
Andrea Cillingová +12 more
doaj +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Background Panax notoginseng is a medicinally important Chinese herb with a long history of cultivation and clinical application. The planting area is mainly distributed in Wenshan Prefecture, where the quality and safety of P.
Guan-Hua Cao +8 more
doaj +1 more source
Magnesium deficiency in sugar beets alters sugar partitioning and phloem loading in young mature leaves [PDF]
Magnesium deficiency has been reported to affect plant growth and biomass partitioning between root and shoot. The present work aims to identify how Mg deficiency alters carbon partitioning in sugar beet (Beta vulgaris L.) plants.
Bourgis, Fabienne +5 more
core

