Results 81 to 90 of about 13,066 (249)
Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack
New Phytologist, Volume 249, Issue 3, Page 1124-1144, February 2026.Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos +6 more
wiley +1 more source
BMC Plant Biology, 2020 Background Panax notoginseng is a medicinally important Chinese herb with a long history of cultivation and clinical application. The planting area is mainly distributed in Wenshan Prefecture, where the quality and safety of P.
Guan-Hua Cao +8 more
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, Volume 600, Issue 2, Page 239-250, January 2026.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE. [PDF]
, 2014 The major facilitator superfamily (MFS) is the largest collection of structurally related membrane proteins that transport a wide array of substrates.
Gonen, Tamir +4 more
core +3 more sources
FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Communication Membrane Systems with Active Symports [PDF]
, 2006 Journal of Automata, Languages and Combinatorics, Volume 11, Number 3, 2006, 241 ...
Brijder, Robert +4 more
openaire +2 more sources
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
Hopanoids Play a Role in Membrane Integrity and pH Homeostasis in Rhodopseudomonas palustris TIE-1 [PDF]
, 2009 Sedimentary hopanes are pentacyclic triterpenoids that serve as biomarker proxies for bacteria and certain bacterial metabolisms, such as oxygenic photosynthesis and aerobic methanotrophy.
Hunter, Ryan C. +5 more
core +3 more sources
Dimerization of the Sodium/Iodide Symporter
Thyroid, 2019 Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson, Rebecca J. +11 more
openaire +2 more sources
ChemBioChem, Volume 27, Issue 1, January 2026.Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh +7 more
wiley +1 more source