Results 1 to 10 of about 256,017 (307)
Neurobiology of Disease, 2020 A number of publications have reported that cysteamine has significant therapeutic effects on several aspects of Parkinson's disease (PD)-related pathology but none of these studies have evaluated its impact on pathological forms of α-Synuclein (α-Syn ...
Martine Saint-Pierre +2 more
exaly +3 more sources
Frontiers in Molecular Neuroscience, 2019 Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated
Zhengcun Wu, Shuaiyao Lu, Kaili Ma
exaly +3 more sources
Limnology and Oceanography, 2019 AbstractSynechococcus is a widespread and important marine primary producer. Time series provide critical information for identifying and understanding the factors that determine abundance patterns. Here, we present the results of analysis of a 16‐yr hourly time series of Synechococcus at the Martha's Vineyard Coastal Observatory, obtained with an ...
Kristen R. Hunter‐Cevera +5 more
openaire +3 more sources
Twenty-three new synonyms of the Eastern common groundhopper, Tetrix japonica (Bolívar, 1887) (Orthoptera, Tetrigidae) [PDF]
ZooKeys, 2023 The Eastern common groundhopper, Tetrix japonica, is a pygmy grasshopper species widely distributed in the Eastern Palearctic region, and shows a high degree of phenotypic variation.
Ying Long +5 more
doaj +3 more sources
Cells, 2023 In the liver, phase-1 biotransformation of drugs and other xenobiotics is largely facilitated by enzyme complexes consisting of cytochrome P450 oxidoreductase (CPR) and cytochrome P450 monooxygenases (CYPs). Generated from human liver-derived cell lines,
Christian Schulz +4 more
doaj +1 more source
Rehabilitation training improves nerve injuries by affecting Notch1 and SYN
Open Medicine, 2020 The aim of this study was to investigate the effects of rehabilitation training on Notch1 and synaptophysin (SYN) levels in brain tissues of rats with chronic cerebral ischemia.
Jing Mao +4 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2022 Parkinson’s disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain. LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn).
Qianqian Cao +11 more
doaj +1 more source
Alpha-Synuclein species in oral mucosa as potential biomarkers for multiple system atrophy
Frontiers in Aging Neuroscience, 2022 BackgroundThe definitive diagnosis of Multiple system atrophy (MSA) requires the evidence of abnormal deposition of α-Synuclein (α-Syn) through brain pathology which is unable to achieve in vivo.
Yuanchu Zheng +5 more
doaj +1 more source
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate
Neurobiology of Disease, 2020 Loss of dopaminergic nigrostriatal neurons and fibrillary α-synuclein (α-syn) aggregation in Lewy bodies (LB) characterize Parkinson's disease (PD). We recently found that Synapsin III (Syn III), a phosphoprotein regulating dopamine (DA) release with α ...
Gaia Faustini +15 more
doaj +1 more source
Oral Mucosa Derived α−Synuclein as a Potential Diagnostic Biomarker for Parkinson′s Disease
Frontiers in Aging Neuroscience, 2022 BackgroundPathological α-synuclein (α-Syn) is not only exclusive to the central nervous system (CNS) in Parkinson’s disease (PD), but also extended to biofluids and peripheral tissues including oral cavity. Both oral mucosa and nervous system are derived
Yuanchu Zheng +7 more
doaj +1 more source