Results 31 to 40 of about 172,297 (259)

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Compassion fatigue in University students in the context of social media consumption

East European Journal of Psycholinguistics
This study examines compassion fatigue in the context of contemporary media consumption, focusing on emotionally saturated news coverage related to war, human loss, destruction, and humanitarian crises. Using a mixed-methods design, the research explores
Halyna Synorub, Tetiana Husieva, Svitlana Buchatska, Bohdana Patuta   +3 more
doaj   +1 more source

Modeling -Synucleinopathy in Organotypic Brain Slice Culture with Preformed -Synuclein Amyloid Fibrils

Journal of Parkinson’s Disease, 2020
Background: Synucleinopathy is a group of neurodegenerative disorders characterized by neurodegeneration and accumulation of alpha-synuclein ( α -syn) aggregates in various brain regions.
Amandine Roux, Xinhe Wang, Katelyn Becker, Jiyan Ma   +3 more
doaj   +1 more source

Alpha-Synuclein Accumulation and Its Phosphorylation in the Enteric Nervous System of Patients Without Neurodegeneration: An Explorative Study

Frontiers in Aging Neuroscience, 2020
Alpha-synuclein (α-Syn) is widely distributed and involved in the regulation of the nervous system. The phosphorylation of α-Syn at serine 129 (pSer129α-Syn) is known to be closely associated with α-Synucleinopathies, especially Parkinson's disease (PD).
Lu-Lu Bu, Lu-Lu Bu, Kai-Xun Huang, Kai-Xun Huang, De-Zhi Zheng, De-Zhi Zheng, Dan-Yu Lin, Dan-Yu Lin, Ying Chen, Ying Chen, Xiu-Na Jing, Xiu-Na Jing, Yan-Ran Liang, Yan-Ran Liang, En-Xiang Tao, En-Xiang Tao   +15 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Polymorphism of bis(1,3-benzothiazol-2-yl) trithiocarbonate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The polymorphism of the title compound, C15H8N2S5, is reported, in which the (syn,syn) and (syn,anti) conformers simultaneously crystallized from a chloroform solution.
Kevin Kafuta, Christopher Golz, Manuel Alcarazo   +2 more
doaj   +1 more source

POM‐Based Water Splitting Catalyst Under Acid Conditions Driven by Its Assembly on Carbon Nanotubes

Advanced Materials, EarlyView.
A newly‐engineered POM‐based electrocatalyst incorporating non‐innocent counter cations exhibits fast kinetics for either the OER or HER under strongly acidic conditions (1 m H2SO4), depending on whether it is assembled on carbon nanotubes (1@CNT) or physically mixed with them (1/CNT). In water‐splitting tests using a two‐electrode setup, these systems
Eugenia P. Quirós‐Díez, Melanie Guillén‐Soler, Carlos Herreros‐Lucas, Alejandro López‐Moreno, José Manuel Vila‐Fungueiriño, Antonio Luis Llamas‐Saiz, Karol Strutyński, Manuel Melle‐Franco, María del Carmen Giménez‐López   +8 more
wiley   +1 more source

Phantom spiders: notes on dubious spider species from Europe

Arachnologische Mitteilungen, 2015
A surprisingly large number of European spider species have never been reliably rediscovered since their first description many decades ago. Most of these are probably synonymous with other species or unidentifiable, due to insufficient descriptions or ...
Breitling, Rainer, Lemke, Martin, Bauer, Tobias, Hohner, Michael, Grabolle, Arno, Blick, Theo   +5 more
doaj   +1 more source

Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response

Frontiers in Molecular Neuroscience, 2019
Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated
Tingfu Du, Tingfu Du, Tingfu Du, Zhengcun Wu, Zhengcun Wu, Haiyu Luo, Haiyu Luo, Shuaiyao Lu, Shuaiyao Lu, Kaili Ma, Kaili Ma, Kaili Ma   +11 more
doaj   +1 more source

A Cu‐Based Near‐IR Active MOF with an Ion‐Pair Guest Exhibiting Versatile and Selective Gas‐Solid Reactivity

Advanced Materials, EarlyView.
The new Cu‐containing MOF (Me2NH2)(CuICl2)@[Cu4(INA)4Cl2O]·1.5dmf (3) contains a cation and an anion as guests and shows UV‐near‐mid‐IR absorption and near‐IR emission. MOF 3 shows gas‐solid reactivity in the presence of NH3 and HCOOH to yield two new 3D MOF.
Rajat Saha, Alejandro Cortés‐Villena, Silvia Gómez‐Coca, Alberto Fernández‐Alarcón, Joaquín Calbo, Raquel E. Galian, Enrique Ortí, Eliseo Ruiz, Mónica Giménez‐Marqués, Samia Benmansour, Carlos J. Gómez‐García   +10 more
wiley   +1 more source