Results 31 to 40 of about 256,017 (307)

Autophagy inhibition enhanced α-syn-associated toxicity in strain A3.

, 2018
(A) The A1-A4 strains, which lack the gene encoding Atg5, were monitored for α-syn mediated toxicity as described above in Fig 1. In contrast to wt, the corresponding strains of A3 and A4 lacking Atg5 grew poorly upon α-syn overexpression.
Richa Pandey (5909060), Anuradhika Puri (814562), Deepak Sharma (131639), Arpit Gupta (814561), Surabhi Sonam (5909057), Prashant Singh (729773)   +5 more
core   +1 more source

Relacje między rodzicami i dziećmi zapisane we frazematyce gwarowej

Annales Universitatis Paedagogicae Cracoviensis. Studia Linguistica
Zbiór frazemów gwarowych z całej Polski zawiera jednostki dotyczące relacji między osobami należącymi do różnych pokoleń. Są to frazemy z nazwami pierwszego stopnia pokrewieństwa pełnego w linii prostej: ojciec, matka, rodzice, syn, córka, dziecko ...
Anna Tyrpa
doaj   +1 more source

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis

Frontiers in Cell and Developmental Biology, 2018
Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which
Wei Hou, Wei Hou, Wing-Kin Syn, Wing-Kin Syn   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Marazm męskości: Wokół opowiadania Olgi Tokarczuk “Przetwory”

Er(r)go
Opowiadanie Olgi Tokarczuk “Przetwory” z tomu Opowiadania bizarne (2018) to przykład literackiej narracji o męskości, która – z powodu braku odpowiedniego wzorca i niedostatecznej autorefleksji – pogrzebała swoją szansę na rozwój. Hermeneutyczna lektura
Iwona Gralewicz-Wolny
doaj   +1 more source

A3 strain reduced α-syn-mediated toxicity.

, 2018
The wt or strains A1-A4 were transformed with either CEN or 2μ plasmid, with or without the gene encoding α-syn, under the strong constitutive GPD promoter. (A) Growth phenotype of transformants after culturing 3 days at 30°C, and 2 days at 25°C. As seen,
Richa Pandey (5909060), Anuradhika Puri (814562), Deepak Sharma (131639), Arpit Gupta (814561), Surabhi Sonam (5909057), Prashant Singh (729773)   +5 more
core   +1 more source

Catalytic Enantioselective Syn-Hydroxy-Oxyacylation of Electron Deficient Alkenes

, 2021
Asymmetric syn-dihydroxylation and dioxyacylation of alkenes have been well established. A direct method for the enantioselective preparation of orthogonally protected syn-1,2-diols from alkenes is unprecedented.
Vikram, Singh, Bhoopendra, Twari, Chandra Bhan, Pandey, Susanta, Ghanta, BHOOPENDRA, TIWARI   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices

Biomolecules, 2022
The accumulation of α-synuclein (α-syn) in the brain plays a role in synucleinopathies and it is hypothesized to spread in a prion-like fashion between connected brain regions.
Buket Uçar, Nadia Stefanova, Christian Humpel   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source