Results 31 to 40 of about 175,000 (211)

Modeling -Synucleinopathy in Organotypic Brain Slice Culture with Preformed -Synuclein Amyloid Fibrils

Journal of Parkinson’s Disease, 2020
Background: Synucleinopathy is a group of neurodegenerative disorders characterized by neurodegeneration and accumulation of alpha-synuclein ( α -syn) aggregates in various brain regions.
Amandine Roux, Xinhe Wang, Katelyn Becker, Jiyan Ma   +3 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Compassion fatigue in University students in the context of social media consumption

East European Journal of Psycholinguistics
This study examines compassion fatigue in the context of contemporary media consumption, focusing on emotionally saturated news coverage related to war, human loss, destruction, and humanitarian crises. Using a mixed-methods design, the research explores
Halyna Synorub, Tetiana Husieva, Svitlana Buchatska, Bohdana Patuta   +3 more
doaj   +1 more source

Alpha-Synuclein Accumulation and Its Phosphorylation in the Enteric Nervous System of Patients Without Neurodegeneration: An Explorative Study

Frontiers in Aging Neuroscience, 2020
Alpha-synuclein (α-Syn) is widely distributed and involved in the regulation of the nervous system. The phosphorylation of α-Syn at serine 129 (pSer129α-Syn) is known to be closely associated with α-Synucleinopathies, especially Parkinson's disease (PD).
Lu-Lu Bu, Lu-Lu Bu, Kai-Xun Huang, Kai-Xun Huang, De-Zhi Zheng, De-Zhi Zheng, Dan-Yu Lin, Dan-Yu Lin, Ying Chen, Ying Chen, Xiu-Na Jing, Xiu-Na Jing, Yan-Ran Liang, Yan-Ran Liang, En-Xiang Tao, En-Xiang Tao   +15 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

Phantom spiders: notes on dubious spider species from Europe

Arachnologische Mitteilungen, 2015
A surprisingly large number of European spider species have never been reliably rediscovered since their first description many decades ago. Most of these are probably synonymous with other species or unidentifiable, due to insufficient descriptions or ...
Breitling, Rainer, Lemke, Martin, Bauer, Tobias, Hohner, Michael, Grabolle, Arno, Blick, Theo   +5 more
doaj   +1 more source

Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response

Frontiers in Molecular Neuroscience, 2019
Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform α-syn-98 is generated
Tingfu Du, Tingfu Du, Tingfu Du, Zhengcun Wu, Zhengcun Wu, Haiyu Luo, Haiyu Luo, Shuaiyao Lu, Shuaiyao Lu, Kaili Ma, Kaili Ma, Kaili Ma   +11 more
doaj   +1 more source

Polymorphism of bis(1,3-benzothiazol-2-yl) trithiocarbonate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The polymorphism of the title compound, C15H8N2S5, is reported, in which the (syn,syn) and (syn,anti) conformers simultaneously crystallized from a chloroform solution.
Kevin Kafuta, Christopher Golz, Manuel Alcarazo   +2 more
doaj   +1 more source

Multilayer Biobased Poly(ethylene furanoate)/Graphene Oxide Nanofibrous Membranes With Directional Water Transport for Efficient Microplastics Filtration

Advanced Materials Technologies, EarlyView.
A self‐assembled multilayer biobased PEF/GO nanofibrous membrane was developed by electrospinning for efficient PLA microplastics (MPs) filtration. The membrane combines superhydrophilicity, directional water transport, mechanical robustness, and a synergistic size‐exclusion interception and electrostatic repulsion MPs separation mechanism, enabling ...
Juraij Kandiyil, Sumayya Ansari, Prasanna Kumar S Mural, Yaser E. Greish, Adnan Younis, Akmal Nazir, Muhammad Z. Iqbal   +6 more
wiley   +1 more source