Results 11 to 20 of about 175,000 (211)

α-Synuclein Forms Distinct Micelle-Like Assemblies at Low Ionic Strengths. [PDF]

Adv Sci (Weinh)
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Hertel S, Ray S, Saraceno F, Nisini G, Nasi G, Mason TO, Kunka A, Agrimaki E, Olesen DJ, Ruggeri FS, Buell AK.   +10 more
europepmc   +2 more sources

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice

Frontiers in Cellular Neuroscience, 2021
Aggregation of misfolded α-synuclein (α-syn) is the major component of Lewy bodies and neurites in Parkinson’s disease (PD) and related α-synucleinopathies.
Hao Gu, Hao Gu, Xiuli Yang, Xiuli Yang, Xiaobo Mao, Xiaobo Mao, Enquan Xu, Enquan Xu, Chen Qi, Chen Qi, Haibo Wang, Haibo Wang, Saurav Brahmachari, Saurav Brahmachari, Bethany York, Bethany York, Manjari Sriparna, Manjari Sriparna, Amanda Li, Amanda Li, Michael Chang, Michael Chang, Pavan Patel, Pavan Patel, Valina L. Dawson, Valina L. Dawson, Valina L. Dawson, Valina L. Dawson, Valina L. Dawson, Ted M. Dawson, Ted M. Dawson, Ted M. Dawson, Ted M. Dawson, Ted M. Dawson   +33 more
doaj   +1 more source

Receptor-Dependent Endocytosis Mediates α-Synuclein Oligomer Transport Into Red Blood Cells

Frontiers in Aging Neuroscience, 2022
Detection of oligomeric α-synuclein (o-α-Syn) in red blood cells (RBCs) has been shown to be promising in diagnosing Parkinson’s disease and other synucleinopathies.
Wei Li, Wei Li, Junya Hu, Junya Hu, Xin Li, Xin Li, Zhe Lu, Zhe Lu, Xuying Li, Chaodong Wang, Chaodong Wang, Shun Yu, Shun Yu   +12 more
doaj   +1 more source

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy [PDF]

Advanced science
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Qu M, Zhang X, Chen X, Shi J, Xu M, Wang F, Lv J, Sun J, Niu W, Liu Z, Li L, Liu F, Wang X.   +12 more
europepmc   +2 more sources

Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview

Frontiers in Immunology, 2017
Antimicrobial peptides (AMPs) are a pervasive and evolutionarily ancient component of innate host defense which is present in virtually all classes of life.
Raheleh Roudi, Nicholas L. Syn, Nicholas L. Syn, Maryam Roudbary   +3 more
doaj   +1 more source

Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance

npj Parkinson's Disease, 2022
The accumulation of α-synuclein (α-syn) in intracellular formations known as Lewy bodies (LBs) is associated with several neurodegenerative diseases including Parkinson’s disease and Lewy Body Dementia.
Cara L. Croft, Giavanna Paterno, Ava R. Vause, Lyla A. Rowe, Daniel H. Ryu, Marshall S. Goodwin, Corey A. Moran, Pedro E. Cruz, Benoit I. Giasson, Todd E. Golde   +9 more
doaj   +1 more source

Tanshinone IIA Regulates Synaptic Plasticity in Mg2+-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway

Journal of Integrative Neuroscience
Background: Tanshinone IIA (TSIIA) is an element of the effective ingredients of Salvia miltiorrhiza Bunge (Labiatae), exhibits a significant therapeutic effect in brain neuroprotection.
Meile Ma, Xi Hua, Chen Jia, Nan Xiao, Li Zhang, Liming Wei, Haisheng Jiao   +6 more
doaj   +1 more source

Stochastic model of TCP SYN attacks / Stochastinis TCP SYN atakų modelis

Mokslas: Lietuvos Ateitis, 2011
A great proportion of essential services are moving into internet space making the threat of DoS attacks even more actual. To estimate the real risk of some kind of denial of service (DoS) attack in real world is difficult, but mathematical and software ...
Simona Ramanauskaitė, Antanas Čenys
doaj   +1 more source

Zadania ojca w świetle prawodawstwa pierwotnego Kościoła

Vox Patrum
Artykułu próbuje ukazać rolę ojca w świetle kanonów pierwotnego Kościoła, począwszy od początków chrześcijaństwa aż po rok 600. Chodzi o takie zagadnienia, jak odpowiedzialność ojca za wiarę i zbawienie dzieci, właściwe wychowanie potomstwa, ochronę ...
Dariusz Piasecki
doaj   +1 more source

The genera of Nematinae (Hymenoptera, Tenthredinidae)

Journal of Hymenoptera Research, 2014
Recent phylogenetic studies on Nematinae based on DNA sequences have shown extensive incongruencies with current nomenclature of genus-group taxa. Here, we expand previous DNA sequence datasets based on three genes (CoI, Cytb, and EF-1α), to include a ...
Marko Prous, Stephan M. Blank, Henri Goulet, Erik Heibo, Andrew Liston, Tobias Malm, Tommi Nyman, Stefan Schmidt, David Smith, Hege Vårdal, Matti Viitasaari, Veli Vikberg, Andreas Taeger   +12 more
doaj   +1 more source