Results 61 to 70 of about 256,017 (307)

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

On the identity of Chauliognathus flavipes (Coleoptera: Cantharidae): revision of type specimens, new synonyms and new status

Zoologia (Curitiba)
The identity, taxonomic history, type series and synonyms of Chauliognathus flavipes (Fabricius, 1781), C. fallax (Germar, 1823), C. axillaris (Fischer von Waldheim, 1823) and C. basalis Lacordaire, 1857 are herein discussed. Twenty-five new synonyms are
Gabriel Biffi
doaj   +1 more source

α-syn-induced dopaminergic neurodegeneration in C. elegans is rescued by MFX.

, 2016
Treatment of α-syn-expressing dopaminergic neurons with psd-1 or crls-1 RNAi, which causes enhanced neurodegeneration compared to α-syn alone, is also rescued by MFX (A—C). Graphical representation of C. elegans strain UA196 [sid-1(pk3321); Pdat-1::α-syn,
Shaoxiao Wang (39561), Floyd Galiano (846724), Kim A. Caldwell (370048), Stephan N. Witt (357686), Dhaval Patel (578884), Addie Barron (3220323), Yong Joo Lee (357685), Siyuan Zhang (2044930), Chuan Xu (293667), Guy A. Caldwell (370065)   +9 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Syn-Selective Michael Addition of Nitromethane Derivatives to Enoates Derived from (R)-(+)-Glyceraldehyde Acetonide

, 2016
We report the syn-selective Michael addition of a series of substituted primary and secondary nitromethane derivatives 4a−g to chiral enoates (Z)-2a and (E)-2a in the presence of TBAF·3H2O or DBU.
Aline L. Anholeto (3038094), Jeronimo S. Costa (3038100), Vera L. Patrocinio (3038097), Paulo R. R. Costa (540240), Mônica D. Monteiro (3038103), Ayres G. Dias (2715244)   +5 more
core   +1 more source

TCP SYN Flood (DoS) Attack Prevention Using SPI Method on CSF: A PoC

, 2020
TCP SYN Flood as one kind of Denial of Service (DoS) attack, still popular to flood the server connection, by sending SYN packets to the target. Because of the risk caused by this attack, there is a need for a network security mechanism.
Pratama, I Putu Agus Eka
core   +1 more source

Διασκευάζοντας για παιδιά ένα μεσαιωνικό θρύλο: Βασίλειος Διγενής Ακρίτας

, 2022
Les œuvres de la littérature orale/folklorique sont, en raison de leur oralité, en perpétuelle évolution et changement. Transférés dans une langue écrite, les « textes » oraux sont à nouveau alimentés par de nouvelles idées et de nouveaux médias et ...
Kanatsouli, Meni
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Η V&V ράβδος ως μέσο αμέσου και ‘ειλικρινούς’ μεταφοράς του αισθητού στο ιδεατό

, 2023
The VV bar is a tool for completing and editing questionnaires, an alternative to Likert scales. It was introduced in 2008 and since then many of the aspects and possibilities it provides to both researchers and informants have been highlighted and ...
Vougiouklis, Thomas, Kambakis-Vougiouklis, Penelope   +1 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source