Results 81 to 90 of about 175,000 (211)

Sulfur‐Boron Lewis Pair‐Catalyzed Hydrohalogenation of Alkynes via Formal Hydrogen Atom Transfer

Angewandte Chemie, EarlyView.
A sulfur‐boron Lewis pair enables the stereodivergent hydrohalogenation of alkynes with exclusive Markovnikov selectivity. Mechanistic studies support a proton transfer‐electron transfer (PT‐ET) sequence for vinyl radical formation rather than a concerted hydrogen atom transfer (HAT) pathway.
Yun Soo Shim, Jin Qian, Sourav Dey, Andrew F. Zahrt, Hyung Min Chi   +4 more
wiley   +2 more sources

Revision of the Traumatomutilla quadrinotata species-group (Hymenoptera: Mutillidae, Sphaeropthalminae): new synonyms, sex associations, and a new species from the Brazilian Atlantic Forest

European Journal of Taxonomy
The Traumatomutilla quadrinotata species-group is reviewed, leaving it with six species known from both sexes, four known from females only and two known from males only.
Pedro R. Bartholomay, Kevin A. Williams, Roberto A. Cambra, Vinícius M. Lopez, Marcio L. Oliveira   +4 more
doaj   +1 more source

RETRACTED ARTICLE: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Acta Neuropathologica Communications, 2017
Neurodegenerative disorders such as Parkinson’s Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons.
Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Anthony Adame, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Dora Games, Robert A. Rissman, Eliezer Masliah   +12 more
doaj   +1 more source

Gold‐Einzelatomkatalysatoren ermöglichen die selektive Shuttle‐Hydrochlorierung von Alkinen

Angewandte Chemie, EarlyView.
Gold‐Einzelatomkatalysatoren auf Aktivkohle ermöglichen dank des Zusammenwirkens zwischen Au(I)‐Zentren und dem Träger die heterogene Shuttle‐Hydrochlorierung von terminalen Alkinen zu Vinylchloriden mit hoher Chemo‐ und Stereoselektivität. Das katalytische System vereint breite Substratverträglichkeit, vereinfachte Abtrennung und Wiederverwertbarkeit ...
Marc‐Eduard Usteri, Eva J. Meeus, Christian Zachau, Seung‐Eun Choi, Aram Bugaev, Milivoj Plodinec, Sharon Mitchell, Bill Morandi, Javier Pérez‐Ramírez   +8 more
wiley   +1 more source

A splice‐switching antisense oligonucleotide targeting APP reduces accumulation of α‐synuclein in a mouse model of Parkinson's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Introduction Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders characterized by abnormal protein aggregation, with amyloid beta (Aβ) and α‐synuclein (α‐syn) as key pathological markers. Increasing evidence highlights a
Rijwan U. Ahammad, Brian Spencer, Bao Quach, Sahar Salehi, Robert A. Rissman   +4 more
doaj   +1 more source

Intramolecular Nickel‐Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles

Angewandte Chemie, EarlyView.
The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner   +3 more
wiley   +1 more source

Synthese von Aminocyclopropanen durch redoxneutrale Aminoalkylierung

Angewandte Chemie, EarlyView.
Wir berichten über eine Synthese von Aminocyclopropanen durch Hydroaminoalkylierung unter Einsatz kostengünstiger, leicht zugänglicher Ausgangsmaterialien. Der Ansatz bietet Orthogonalität zu gängigen Methoden und ermöglicht eine breite Toleranz gegenüber funktionellen Gruppen.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science
The spread or transmission of pathologic α‐synuclein (α‐Syn) is emerging as potentially important driver of Parkinson's disease (PD) pathogenesis. Emerging evidence suggests that astrocytes play an important role in uptake/clearance of extracellular α ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
doaj   +1 more source

Serological Indicators and Survival Analysis of Synaptophysin‐Positive Gastric Cancer Patients: A Retrospective Study

iLABMED
Background This study aims to determine prognostic indicators of synaptophysin (SYN) positive gastric cancer with neuroendocrine type by analyzing differences in serological indicators and survival between SYN‐positive and SYN‐negative gastric cancer ...
Xuemei Wei, Xu Zhang, Jiaqi Zhang, Lin Zhu, Guanghong Guo   +4 more
doaj   +1 more source

Gold Single‐Atom Catalysts Enable Selective Shuttle Hydrochlorination of Alkynes

Angewandte Chemie International Edition, EarlyView.
Gold single‐atom catalysts on activated carbon enable heterogeneous shuttle hydrochlorination of terminal alkynes to vinyl chlorides with high chemo‐ and stereo‐selectivity thanks to cooperation between Au(I) sites and the support. The catalytic system combines broad substrate compatibility, simplified separation, and recoverability, paving the way for
Marc‐Eduard Usteri, Eva J. Meeus, Christian Zachau, Seung‐Eun Choi, Aram Bugaev, Milivoj Plodinec, Sharon Mitchell, Bill Morandi, Javier Pérez‐Ramírez   +8 more
wiley   +1 more source