Results 91 to 100 of about 256,017 (307)

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Contribuzioni alla conoscenza dei Coleophoridae. CX. Alcune note sui Coleophoridae descritti da Ioan NemeŞ negli anni 2003 e 2004 (Lepidoptera: Coleophoridae)

SHILAP, 2005
Hemos examinado las 19 especies de Coleophoridae descritas recientemente por Ioan Nemer. En base al examen del aparato genital del material típico, venimos a establecer las siguientes nuevas sinonimias: Coleophora partitella Zeller, 1849 = Ischnophanes
G. Baldizzone
doaj  

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

syn,syn-15,17-Di-2-naphthylhexacyclo[10.2.1.13,10.15,8.02,11.04,9]heptadecane deuterochloroform monosolvate

Acta Crystallographica Section E, 2009
The main molecule of the title compound, C37H36·CDCl3, is a hydrocarbon with two naphthalene segments attached to opposite ends of a rigid norbornylogous spacer with an overall structure that is approximately C-shaped. The dihedral angle between
Andrew F. DeBlase, Darence Ca Thong, Jocelyn M. Nadeau, David Gebhart, Jonathan Provo, Bruce M. Foxman   +5 more
doaj   +1 more source

TCP SYN Cookie Vulnerability

CoRR, 2018
TCP SYN Cookies were implemented to mitigate against DoS attacks. It ensured that the server did not have to store any information for half-open connections. A SYN cookie contains all information required by the server to know the request is valid.
Dakshil Shah, Varshali Kumar
openaire   +2 more sources

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

PERCIFAL - Perceptiv rumslig analys av färg och rum

, 2011
PERCIFAL -Perceptiv analys av färg och ljus- presenterar begrepp och metodiska ramar för beskrivning och analys av visuell upplevelse i rumsliga sammanhang.
Klarén, Ulf
core  

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

AI‐BioMech: Deep Learning Prediction of Mechanical Behavior in Aperiodic Biological Cellular Materials

Advanced Intelligent Discovery, EarlyView.
AI‐BioMech is a deep learning framework that predicts the mechanical behavior of biological cellular materials directly from 2D images. By replacing traditional finite element analysis with semantic segmentation, it identifies stress and strain distributions with 99% accuracy, offering a high‐speed, scalable alternative for analyzing complex, aperiodic
Haleema Sadia, Marcelo A. Dias, Parvez Alam   +2 more
wiley   +1 more source

Time‐Delayed Spiking Reservoir Computing Enables Efficient Time Series Prediction

Advanced Intelligent Systems, EarlyView.
This study proposes time‐delayed spiking reservoir computing (TDSRC) for efficient time series prediction. By concatenating time‐lagged states, TDSRC constructs an expanded readout feature vector without altering internal reservoir dynamics. This approach enables highly accurate forecasting with significantly fewer neurons, providing a resource ...
Pin Jin, Ren Cao, Zhongxue Gan, Siyang Leng   +3 more
wiley   +1 more source