Results 71 to 80 of about 256,017 (307)
Age-dependent distribution changes in α-syn-positive and TH-positive neurons in the SNc.
, 2016 A: Number of α-syn-positive or TH-positive neurons in the area of 1 mm2. The red or black line with filled squares represents the α-syn-positive or TH-positive neuron number, respectively.
Fumiaki Tanaka (7313) +4 more
core +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Synthesis of mono Cytochrome P450 in a modified CHO-CPR cell-free protein production platform
Scientific ReportsCytochromes P450 (CYPs) are a group of monooxygenases that can be found in almost all kinds of organisms. For CYPs to receive electrons from co-substrate NADPH, the activity of NADPH-Cytochrome-P450-oxidoreductase (CPR) is required as well.
Jan Felix Knauer +6 more
doaj +1 more source
SYN-TES 2010-2011 Interdisciplinära studier om färg – ljus – rum
, 2012 Det tvärvetenskapliga projektet SYN-TES. Människa, färg och ljus. Syntetisering för ett sammanhållet kunskapsfält har pågått på Konstfack under 2010-2011, med finansiering från KK-stiftelsen (ref. nr 2009/0195).
Fridell Anter, Karin +4 more
core
Co-localization of α-syn-GFP with autophagosomes, or vacuoles was higher in A3 than in A2 cells.
, 2018 Both strains A2 and A3 co-expressed α-syn-GFP and mCherry-Atg8. (A) Confocal microscopy images of representative cells. The α-syn-GFP expression was induced in galactose media for 12 h prior to collecting the cells for analysis by confocal microscopy. (B)
Richa Pandey (5909060) +5 more
core +1 more source
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Journal of Parkinson’s Disease, 2016 Background: The formation of intracellular aggregates containing α-synuclein (α-syn) is a main pathological feature of Parkinson disease. The propagation of α-syn aggregation via cell-to-cell transmission has been implicated in the progression of ...
Yasuhiko Izumi +4 more
doaj +1 more source
Neurobiology of Disease, 2019 It has been suggested that aggregation of α-synuclein (α-syn) into oligomers leads to neurodegeneration in Parkinson's disease (PD), but intravenous immunoglobulin (IVIG) which contains antibodies against α-syn monomers and oligomers fails to treat PD ...
Ya-ru Huang +9 more
doaj +1 more source
α-syn-induced dopaminergic neurodegeneration in C. elegans is rescued by choline chloride.
, 2016 Treatment of α-syn-expressing dopaminergic neurons with psd-1 or crls-1 RNAi, which causes enhanced neurodegeneration compared to α-syn alone, is also rescued by choline chloride (A, B). Graphical representation of C. elegans strain UA196 [sid-1(pk3321);
Shaoxiao Wang (39561) +9 more
core +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source