Results 91 to 100 of about 531,184 (380)

Spin-Based Neuron Model with Domain Wall Magnets as Synapse

, 2012
We present artificial neural network design using spin devices that achieves ultra low voltage operation, low power consumption, high speed, and high integration density.
Augustine, Charles, Panagopoulos, Georgios, Roy, Kaushik, Sharad, Mrigank   +3 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Homogeneous Spiking Neuromorphic System for Real-World Pattern Recognition [PDF]

, 2015
A neuromorphic chip that combines CMOS analog spiking neurons and memristive synapses offers a promising solution to brain-inspired computing, as it can provide massive neural network parallelism and density.
Saxena, Vishal, Wu, Xinyu, Zhu, Kehan
core   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The Role of Non-Destructive Testing of Composite Materials for Aerospace Applications

NDT - Journal of Non-Destructive Testing
This review examines the essential application of non-destructive testing (NDT) techniques in assessing the integrity and damage of composite materials used in aerospace engineering, focusing on polymer matrix composites (PMCs), metal matrix composites ...
Thiago Luiz Lara Oliveira, Maha Hadded, Saliha Mimouni, Renata Brandelli Schaan   +3 more
doaj   +1 more source

Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses following Noise-Induced Cochlear Synaptopathy [PDF]

, 2023
Vijayprakash Manickam, Dinesh Y. Gawande, Andrew R. Stothert, Anna C. Clayman, Lyudmila Batalkina, Mark E. Warchol, Kevin K. Ohlemiller, Tejbeer Kaur   +7 more
openalex   +1 more source

On-chip photonic synapse

Science Advances, 2017
An on-chip photonic device mimics the function of synaptic connections between neurons. The search for new “neuromorphic computing” architectures that mimic the brain’s approach to simultaneous processing and storage of information is intense.
Zengguang Cheng, C. Ríos, Wolfram H. P. Pernice, C. D. Wright, H. Bhaskaran   +4 more
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Procoagulant off-target effect of the direct oral anticoagulant reversal agent Andexanet alfa

Blood Vessels, Thrombosis & Hemostasis
: Patients with hemorrhage after treatment with direct oral anticoagulants (DOACs) are saved from hematoma expansion by administration of Andexanet alfa, a modified factor Xa analog.
Ischa M. S. Hoornstra, Junxiong Zhao, Harmen Middelveld, Siyu Sun, Claudia Schönichen, Johan W. M. Heemskerk, Hendrik Stragier, René Heylen, Bas de Laat, Mark Roest   +9 more
doaj   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source