Results 91 to 100 of about 421,951 (351)

GeNN: a code generation framework for accelerated brain simulations [PDF]

, 2015
Large-scale numerical simulations of detailed brain circuit models are important for identifying hypotheses on brain functions and testing their consistency and plausibility. An ongoing challenge for simulating realistic models is, however, computational
AJ Cope, C Rossant, DF Goodman, DF Goodman, E Ros, EM Izhikevich, EM Izhikevich, HÜ Dinkelbach, I Raikov, J Baladron, JM Nageswaran, MA Swertz, ML Hines, NF Rulkov, P Gleeson, R Brette, SC Eisenstat, T Nowotny, T Nowotny, VK Pallipuram   +19 more
core   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Analog hardware for learning neural networks [PDF]

, 1991
This is a recurrent or feedforward analog neural network processor having a multi-level neuron array and a synaptic matrix for storing weighted analog values of synaptic connection strengths which is characterized by temporarily changing one connection ...
Eberhardt, Silvio P.
core   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Spontaneous Activity Patterns Are Altered in the Developing Visual Cortex of the Fmr1 Knockout Mouse

Frontiers in Neural Circuits, 2019
Fragile X syndrome (FXS) is the most prevalent inherited cause of autism and is accompanied by behavioral and sensory deficits. Errors in the wiring of the brain during early development likely contribute to these deficits, but the underlying mechanisms ...
Juliette E. Cheyne, Nawal Zabouri, David Baddeley, Christian Lohmann, Christian Lohmann   +4 more
doaj   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source

Energy efficiency of information transmission by electrically coupled neurons

, 2012
The generation of spikes by neurons is energetically a costly process. This paper studies the consumption of energy and the information entropy in the signalling activity of a model neuron both when it is supposed isolated and when it is coupled to ...
Abarbanel, Abdelmalik Moujahid, Alicia d’Anjou, Attwell, Balasubramanian, Belykh, Cecilia Sarasola, Clarke, Connors, Dhamala, Donald, FitzHugh, Francisco J. Torrealdea, Galarreta, Hansel, Hasegawa, Hayashi, Herz, Hindmarsh, Hodgkin, Huerta, Kasischke, Kepler, Koch, Kolb, Lago-Fernandez, Laughlin, Lennie, Levy, Levy, Mackay, Morrison, N. Vélez de Mendizábal, Nagai, Nemenman, Olver, Ozden, Pinto, Rieke, Rose, Rose, Rose, Rose, Rosenblum, Roy, Rulkov, Sarasola, Schreiber, Selverston, Shannon, Siekevitz, Smith, Strong, Torrealdea, Torrealdea, Venaille, Veruki, Veruki, Vincent, Wu, Yoshioka   +60 more
core   +1 more source

Synergies at the synapse [PDF]

British Journal of Pharmacology, 2003
British Journal of Pharmacology (2003) 138, 1387–1388.
openaire   +3 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Proteomic Analysis of Dendritic Filopodia-Rich Fraction Isolated by Telencephalin and Vitronectin Interaction

Frontiers in Synaptic Neuroscience, 2018
Dendritic filopodia are thin, long, and highly mobile protrusions functioning as spine precursors. By contrast with a wealth of knowledge on molecular profiles in spines, little is known about structural and functional proteins present in dendritic ...
Yutaka Furutani, Yoshihiro Yoshihara, Yoshihiro Yoshihara   +2 more
doaj   +1 more source