Results 11 to 20 of about 140,328 (150)

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process

Frontiers in Cardiovascular Medicine, 2022
Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai, Cuicui Bai, Joke Konings, Joke Konings, Marisa Ninivaggi, Marcus Lancé, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +8 more
doaj   +1 more source

Reference values for thrombin dynamics in platelet rich plasma

Platelets, 2021
Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan, Marisa Ninivaggi, Bas de Laat, Romy M. W. de Laat-Kremers   +3 more
doaj   +1 more source

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +1 more source

ST Genesia reference values of 117 healthy donors measured with STG‐BleedScreen, STG‐DrugScreen and STG‐ThromboScreen reagents

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement.
Marisa Ninivaggi, Romy M. W. deLaat‐Kremers, Audrey Carlo, Bas deLaat   +3 more
doaj   +1 more source

Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile

Frontiers in Cardiovascular Medicine, 2022
BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li, Li Li, Mark Roest, Yaqiu Sang, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Dana Huskens, Jun Wan, Jun Wan, Bas de Laat, Bas de Laat, Joke Konings, Joke Konings   +15 more
doaj   +1 more source

Combining human platelet proteomes and transcriptomes: possibilities and challenges

Platelets, 2023
The anucleate human platelets contain a broad pattern of mRNAs and other RNA transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from different sources points to a common origin, and suggests a random redistribution of ...
Jingnan Huang, Johan W.M. Heemskerk, Frauke Swieringa   +2 more
doaj   +1 more source

Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort

Frontiers in Cardiovascular Medicine, 2022
The coagulation system can be assessed by the thrombin generation (TG) assay, and increased TG peak height, endogenous thrombin potential (ETP), and velocity index are associated with an increased risk of thrombosis. Obesity had been reported to increase
Romy de Laat-Kremers, Augusto Di Castelnuovo, Lisa van der Vorm, Simona Costanzo, Marisa Ninivaggi, Chiara Cerletti, Dana Huskens, Dana Huskens, Amalia De Curtis, Alessandro Gialluisi, Alessandro Gialluisi, Cuicui Bai, Cuicui Bai, Giovanni de Gaetano, Dongmei Yin, Maria Benedetta Donati, Bas de Laat, Bas de Laat, Bas de Laat, Licia Iacoviello, Licia Iacoviello, The Moli-sani Investigators   +21 more
doaj   +1 more source

Synaptic basis of a sub-second representation of time in a neural circuit model

Nature Communications, 2022
Neural circuit dynamics are thought to drive temporally precise actions. Here, the authors used a theoretical approach to show that synapses endowed with diverse short-term plasticity can act as tunable timers sufficient to generate rich neural dynamics.
A. Barri, M. T. Wiechert, M. Jazayeri, D. A. DiGregorio   +3 more
doaj   +1 more source

Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation

Scientific Reports, 2021
Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make the blood clot.
Romy M. W. de Laat-Kremers, Marisa Ninivaggi, Iris van Moort, Moniek de Maat, Bas de Laat   +4 more
doaj   +1 more source

A Hypoxic Environment Attenuates Exercise-Induced Procoagulant Changes Due to Decreased Platelet Activation

TH Open, 2019
Introduction Although physical exercise is protective against cardiovascular disease, it can also provoke sudden cardiac death (exercise paradox).
Cécile H. Kicken, Lisa N. van der Vorm, Suzanne Zwaveling, Evi Schoenmaker, Jasper A. Remijn, Dana Huskens, Bas de Laat   +6 more
doaj   +1 more source