Results 11 to 20 of about 531,184 (380)
Huntingtin and the Synapse [PDF]
Frontiers in Cellular Neuroscience, 2021 Huntington disease (HD) is a monogenic disease that results in a combination of motor, psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT).
Barron, Jessica C. +2 more
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Cell, 2004 The transmission of information across neuronal synapses is an energetically taxing business. Sheng and colleagues monitored the localization of mitochondria following different levels of synaptic activation and discovered that these organelles change their distribution in interesting ways, stalling near synapses when neurons are activated and ...
Schuman, E., Chan, D.
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Neuron, 2013 The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
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Probabilistic Fluorescence-Based Synapse Detection [PDF]
, 2016 Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in hundreds of ...
Aguerrebere, Cecilia +7 more
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Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
Journal of Clinical Investigation, 2020 Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we have demonstrated a potent IFN immunogenicity of nucleic acid (NA)-containing amyloid fibrils in the periphery.
Ethan R. Roy +15 more
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The History of the Synapse [PDF]
The Anatomical Record, 2020 ABSTRACTWhy did I choose this particular topic for my lecture rather than the history of neuroscience or the history of the neuron? Simply because I believe that every disciple has the obligation to pay homage to their mentors once in their lifetime. My formation as a neuroscientist involved three such mentors spanned across three countries.
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Autophagy at the synapse [PDF]
Neuroscience Letters, 2019 As the sites of communication between neurons, synapses depend upon precisely regulated protein-protein interactions to support neurotransmitter release and reception. Moreover, neuronal synapses typically exist great distances (i.e. up to meters) away from cell bodies, which are the sources of new proteins and the major sites of protein degradation ...
Veronica Birdsall, Clarissa L. Waites
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cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]
, 2015 A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
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The Journal of Neuroscience, 1996 The strength of many synapses is modified by various use and time-dependent processes, including facilitation and depression. A general description of synaptic transfer characteristics must account for the history-dependence of synaptic efficacy and should be able to predict the postsynaptic response to any temporal pattern of presynaptic activity.
K, Sen +3 more
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TH Open, 2019 Introduction Although physical exercise is protective against cardiovascular disease, it can also provoke sudden cardiac death (exercise paradox).
Cécile H. Kicken +6 more
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