Results 11 to 20 of about 266,135 (309)
Synaptic basis of a sub-second representation of time in a neural circuit model
Nature Communications, 2022 Neural circuit dynamics are thought to drive temporally precise actions. Here, the authors used a theoretical approach to show that synapses endowed with diverse short-term plasticity can act as tunable timers sufficient to generate rich neural dynamics.
A. Barri +3 more
doaj +1 more source
Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort
Frontiers in Cardiovascular Medicine, 2022 The coagulation system can be assessed by the thrombin generation (TG) assay, and increased TG peak height, endogenous thrombin potential (ETP), and velocity index are associated with an increased risk of thrombosis. Obesity had been reported to increase
Romy de Laat-Kremers +21 more
doaj +1 more source
Synapses immunologiques et synapses neuronales [PDF]
médecine/sciences, 2003 Les systemes nerveux et immunitaire ont en commun de constituer dans l’organisme des reseaux complexes de cellules en interaction. Dans ces reseaux transitent en permanence d’enormes quantites d’informations, codees de facon tres differente dans les deux cas. Ces informations doivent en particulier circuler de cellule en cellule.
Trautmann, Alain +3 more
openaire +2 more sources
Scientific Reports, 2021 Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make the blood clot.
Romy M. W. de Laat-Kremers +4 more
doaj +1 more source
Frontiers in Psychiatry, 2021 COVID-19 Pandemic has influenced death-related attitudes and understanding during the childhood development leading to a life-long impact. Factors like pandemic-related movement restrictions, school closures, and parents' stay-at-home have exposed ...
Aisha Sanober Chachar +2 more
doaj +1 more source
Frontiers in Neuroscience, 2022 Given the significance of validating reliable tests for the early detection of autism spectrum disorder (ASD), this systematic review aims to summarize available evidence of neuroimaging and neurophysiological changes in high-risk infants to improve ASD ...
Cullen Clairmont +7 more
doaj +1 more source
Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling
Nature Communications, 2020 NMDA receptor-dependent long-term depression (NMDAR-LTD) is a form of synaptic plasticity mediated by reduced recycling of AMPA receptors to the plasma membrane.
Hongmei Shen +4 more
doaj +1 more source
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
Nature Communications, 2017 Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit ...
Yuko Tanabe +6 more
doaj +1 more source
Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
TH Open, 2018 Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von ...
Lisa N. van der Vorm +3 more
doaj +1 more source
Activity-dependent regulation of mitochondrial motility in developing cortical dendrites
eLife, 2021 Developing neurons form synapses at a high rate. Synaptic transmission is very energy-demanding and likely requires ATP production by mitochondria nearby.
Catia AP Silva +5 more
doaj +1 more source