Results 11 to 20 of about 37,262 (199)

Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation

Scientific Reports, 2021
Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make the blood clot.
Romy M. W. de Laat-Kremers, Marisa Ninivaggi, Iris van Moort, Moniek de Maat, Bas de Laat   +4 more
doaj   +1 more source

A Hypoxic Environment Attenuates Exercise-Induced Procoagulant Changes Due to Decreased Platelet Activation

TH Open, 2019
Introduction Although physical exercise is protective against cardiovascular disease, it can also provoke sudden cardiac death (exercise paradox).
Cécile H. Kicken, Lisa N. van der Vorm, Suzanne Zwaveling, Evi Schoenmaker, Jasper A. Remijn, Dana Huskens, Bas de Laat   +6 more
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

eLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne, Maureen H McFadden, David A DiGregorio   +2 more
doaj   +1 more source

Developmental Understanding of Death and Grief Among Children During COVID-19 Pandemic: Application of Bronfenbrenner's Bioecological Model

Frontiers in Psychiatry, 2021
COVID-19 Pandemic has influenced death-related attitudes and understanding during the childhood development leading to a life-long impact. Factors like pandemic-related movement restrictions, school closures, and parents' stay-at-home have exposed ...
Aisha Sanober Chachar, Sana Younus, Wamiq Ali   +2 more
doaj   +1 more source

The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review

Frontiers in Neuroscience, 2022
Given the significance of validating reliable tests for the early detection of autism spectrum disorder (ASD), this systematic review aims to summarize available evidence of neuroimaging and neurophysiological changes in high-risk infants to improve ASD ...
Cullen Clairmont, Jiuju Wang, Jiuju Wang, Samia Tariq, Hannah Tayla Sherman, Mingxuan Zhao, Xue-Jun Kong, Xue-Jun Kong   +7 more
doaj   +1 more source

Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review

TH Open, 2018
Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von ...
Lisa N. van der Vorm, Jasper A. Remijn, Bas de Laat, Dana Huskens   +3 more
doaj   +1 more source

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

Nature Communications, 2020
NMDA receptor-dependent long-term depression (NMDAR-LTD) is a form of synaptic plasticity mediated by reduced recycling of AMPA receptors to the plasma membrane.
Hongmei Shen, Huiwen Zhu, Debabrata Panja, Qinhua Gu, Zheng Li   +4 more
doaj   +1 more source

Coagulation parameters predict COVID-19-related thrombosis in a neural network with a positive predictive value of 98%

Frontiers in Immunology, 2022
Thrombosis is a major clinical complication of COVID-19 infection. COVID-19 patients show changes in coagulation factors that indicate an important role for the coagulation system in the pathogenesis of COVID-19.
Romy de Laat-Kremers, Raf De Jongh, Raf De Jongh, Marisa Ninivaggi, Aernoud Fiolet, Rob Fijnheer, Jasper Remijn, Bas de Laat, Bas de Laat   +8 more
doaj   +1 more source

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

Nature Communications, 2017
Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit ...
Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W. Linhoff, Hideto Takahashi   +6 more
doaj   +1 more source

Thrombin generation in low plasma volumes

Thrombosis Journal, 2018
Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.
Saartje Bloemen, Hilde Kelchtermans, H. Coenraad Hemker   +2 more
doaj   +1 more source