Results 261 to 270 of about 449,578 (382)
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Activity-dependent synapse elimination requires caspase-3 activation. [PDF]
ElifeYu Z, Gutu A, Kim N, O'Shea EK.
europepmc +1 more source
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou +16 more
wiley +1 more source
IMPAIRED SYNAPTIC DYNAMICS TRIGGERED BY SLEEP/WAKE CYCLE IN SYNGAP+/- MICE.
IBRO Neuroscience Reports, 2023 Diego Del Castillo-Berges +2 more
doaj
Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases. [PDF]
Mol NeurodegenerChoi Y, Chung WS.
europepmc +1 more source
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song +9 more
wiley +1 more source
Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain. [PDF]
Nat CommunYousefpour N +27 more
europepmc +1 more source
The effect of a preceding stimulus on temporal facilitation at corticomotoneuronal synapses
, 1973 R. B. Muir, R. Porter
openalex +2 more sources