Results 281 to 290 of about 421,951 (351)

Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Kim HB, Yoo S, Kwak H, Ma SX, Kim R, Lee M, Ha N, Pyo S, Kwon SG, Cho EH, Lee SM, Jang J, Kim WK, Park HC, Baek M, Park Y, Park JY, Park JW, Hwang SW, Hwang JI, Seong JY.   +20 more
europepmc   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Co-Conservation of synaptic gene expression and circuitry in collicular neurons. [PDF]

Nat Commun
Liu Y, McDaniel JA, Chen C, Yang L, Kipcak A, Savier EL, Erisir A, Cang J, Campbell JN.   +8 more
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

A primary mechanism for efficacy of the ketogenic diet may be energy repletion at the tripartite synapse. [PDF]

J Neural Eng
Joshi SN, Joshi AN, Joshi ND.
europepmc   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Lippert A, Rochussen A, Kebabci A, Winkel A, Franze K, Fletcher D, Griffiths G.   +6 more
europepmc   +1 more source

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells. [PDF]

Sci Adv
Lorente-Echeverría B, Daaboul D, Vandensteen J, Marcassa G, Naert W, Vandenbempt J, Leysen E, Reverendo M, Vlaeminck I, Vervloessem L, Lamote J, Poovathingal S, Davie K, Wierda K, Dascenco D, Aerts S, de Wit J.   +16 more
europepmc   +1 more source

Phase‐Change Materials for Volatile Threshold Resistive Switching and Neuronal Device Applications

Advanced Science, EarlyView.
Volatile threshold switching materials are an important pathway to simulate neuronal behavior. This review summarizes recent advances in the development of volatile resistive switching devices and neuronal oscillators based on three representative phase change materials, emphasizes the major challenges in this rapidly evolving field, and provides an ...
Huandong Chen, Jayakanth Ravichandran
wiley   +1 more source