Results 51 to 60 of about 140,328 (150)

Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome

Frontiers in Immunology
IntroductionUnfolded Von Willebrand Factor (VWF) is increased in thrombotic pathologies such as myocardial infarction. Unfolded VWF mediates the binding of platelets without the need for collagen.
Romy de Laat-Kremers, Shengshi Huang, Shengshi Huang, Hugo ten Cate, Hugo ten Cate, Marisa Ninivaggi, Bas de Laat, Bas de Laat, Katrien Devreese, Katrien Devreese   +9 more
doaj   +1 more source

Clustered synapses develop in distinct dendritic domains in visual cortex before eye opening

eLife
Synaptic inputs to cortical neurons are highly structured in adult sensory systems, such that neighboring synapses along dendrites are activated by similar stimuli.
Alexandra H Leighton, Juliette E Cheyne, Christian Lohmann   +2 more
doaj   +1 more source

Astrocytes Control Synapse Formation, Function, and Elimination.

Cold Spring Harbor Perspectives in Biology, 2015
Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of
Won-Suk Chung, N. J. Allen, C. Eroglu
semanticscholar   +1 more source

Characterisation of the Volatile Compounds and Key Odourants in Japanese Mandarins by Gas Chromatography–Mass Spectrometry and Gas Chromatography–Olfactometry

Separations
Japanese mandarins are becoming increasingly popular due to their pleasant aroma. The volatiles in four varieties of Japanese mandarins (Iyokan, Ponkan, Shiranui, and Unshiu mikan) were extracted by headspace solid-phase microextraction (HS-SPME) and ...
Lingyi Li, Rui Min Vivian Goh, Yunle Huang, Kim-Huey Ee, Aileen Pua, Daphne Tan, Shanbo Zhang, Lionel Jublot, Shao Quan Liu, Bin Yu   +9 more
doaj   +1 more source

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Journal of Neuroscience, 2007
Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment.
G. Shankar, Brenda L. Bloodgood, Matthew Townsend, D. Walsh, D. Selkoe, B. Sabatini   +5 more
semanticscholar   +1 more source

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

Frontiers in Cellular Neuroscience, 2019
Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to ...
C. Henstridge, Makis Tzioras, R. Paolicelli   +2 more
semanticscholar   +1 more source

An NMDA Receptor-Dependent Mechanism Underlies Inhibitory Synapse Development

Cell Reports, 2016
In the mammalian brain, GABAergic synaptic transmission provides inhibitory balance to glutamatergic excitatory drive and controls neuronal output. The molecular mechanisms underlying the development of GABAergic synapses remain largely unclear. Here, we
Xinglong Gu, Liang Zhou, Wei Lu
doaj   +1 more source

Flexible three-dimensional artificial synapse networks with correlated learning and trainable memory capability

Nature Communications, 2017
If a three-dimensional physical electronic system emulating synapse networks could be built, that would be a significant step toward neuromorphic computing.
Chaoxing Wu, Tae Whan Kim, Hwan Young Choi, D. Strukov, J. Yang   +4 more
semanticscholar   +1 more source

THE FUNCTION OF THE PROXIMAL SYNAPSES OF THE SQUID STELLATE GANGLION [PDF]

, 1959
S. H. Bryant
openalex   +1 more source

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Nature, 2013
To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodelling. Recently, microglial cells have been shown to be responsible for a portion of synaptic pruning, but the ...
Won-Suk Chung, L. Clarke, Gordon X. Wang, Benjamin K. Stafford, A. Sher, C. Chakraborty, Julia Joung, L. Foo, Andrew Thompson, Chinfei Chen, Stephen J. Smith, B. Barres   +11 more
semanticscholar   +1 more source