Results 51 to 60 of about 531,184 (380)

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

The Immunological Synapse

Annual Review of Immunology, 2001
The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Bromley, S, Burack, W, Johnson, K, Somersalo, K, Sims, T, Sumen, C, Davis, M, Shaw, A, Allen, P, Dustin, M   +9 more
openaire   +3 more sources

Correction to: Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

BMC Cancer, 2019
Following publication of the original article [1], the authors have re-evaluated the authorship for this article. The updated author group is:
Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im   +10 more
doaj   +1 more source

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks

Frontiers in Neurology, 2022
The IMI public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA) was launched in 2008 with an initial budget of €2 billion.
Diana O'Rourke, Nina Coll-Padrós, Angela Bradshaw, Lewis Killin, Laurent Pradier, Jean Georges, Dalia M. Dawoud, Dalia M. Dawoud, Lennert Steukers, Carlos Diaz   +9 more
doaj   +1 more source

Artificial van der Waals hybrid synapse and its application to acoustic pattern recognition

Nature Communications, 2020
Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data.
Seunghwan Seo, Beom‐Seok Kang, Je-Jun Lee, Hyo-Jun Ryu, Sungjun Kim, Hyeongjun Kim, Seyong Oh, Jaewoo Shim, K. Heo, Saeroonter Oh, Jin-Hong Park   +10 more
semanticscholar   +1 more source

Four-quadrant one-transistor-synapse for high-density CNN implementations [PDF]

, 1998
Presents a linear four-quadrants, electrically-programmable, one-transistor synapse strategy applicable to the implementation of general massively-parallel analog processors in CMOS technology.
Carmona Galán, Ricardo, Domínguez Castro, Rafael, Espejo Meana, Servando Carlos, Rodríguez Vázquez, Ángel Benito   +3 more
core   +1 more source

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

bioRxiv, 2019
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes.
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, S. Ha, Nicholas J. Luciano, Cory M Willis, G. Gao, S. Crocker, B. Popko, D. Reich, D. Schafer   +10 more
semanticscholar   +1 more source

Automated Imaging and Analysis of Platelet, Coagulation and Fibrinolysis Activities Using a Novel Flow Chip-Based System at Physiological Temperature

Micromachines
Conventional whole-blood flow assays for quantifying thrombus formation are typically performed at room temperature and are technically demanding, which limits their translational applicability.
Xiang Gui, Bibian M. E. Tullemans, Bas de Laat, Johan W. M. Heemskerk, Frauke Swieringa   +4 more
doaj   +1 more source

Abacavir use is associated with increased prothrombin conversion

Frontiers in Immunology, 2023
There is ongoing debate as to whether abacavir (ABC) increases the risk for cardiovascular disease(CVD) in people living with HIV (PLHIV) and the mechanisms underlying this possible association.
Qiuting Yan, Qiuting Yan, Shengshi Huang, Shengshi Huang, Wouter van der Heijden, Marisa Ninivaggi, Lisa van de Wijer, Romy de Laat-Kremers, Andre J. Van der Ven, Bas de Laat, Bas de Laat, Quirijn de Mast   +11 more
doaj   +1 more source

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Nature Neuroscience, 2019
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remain a key open question ...
Georgia Gunner, Lucas Cheadle, Kasey M. Johnson, Pinar Ayata, Ana Badimon, Erica Mondo, Aurel Nagy, Liwang Liu, S. Bemiller, Ki-Wook Kim, S. Lira, B. Lamb, A. Tapper, R. Ransohoff, M. Greenberg, A. Schaefer, D. Schafer   +16 more
semanticscholar   +1 more source