Results 51 to 60 of about 449,578 (382)

Proteomics of synapse [PDF]

Analytical and Bioanalytical Chemistry, 2006
Large-scale phosphoproteome analysis on synaptosome and preparation of post-synaptic density (PSD) were investigated. It was found that protein phosphor is a common event in the synapse, which is consistent with the presence of diverse classes of kinases and phosphatases in the synapse.
openaire   +4 more sources

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

bioRxiv, 2019
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes.
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, S. Ha, Nicholas J. Luciano, Cory M Willis, G. Gao, S. Crocker, B. Popko, D. Reich, D. Schafer   +10 more
semanticscholar   +1 more source

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

Synapse efficiency diverges due to synaptic pruning following over-growth

, 2003
In the development of the brain, it is known that synapses are pruned following over-growth. This pruning following over-growth seems to be a universal phenomenon that occurs in almost all areas -- visual cortex, motor area, association area, and so on ...
A.W. Roe, C.J. Perez-Vincente, D.J. Amit, D.J. Amit, G. Chechik, G.M. Innocenti, H. Sompolinsky, H. Yanai, I. Meilijson, J. Buhmann, J. Takacs, J.P. Bourgeois, J.R. Wolff, K. Mimura, K. Mimura, Kazushi Mimura, M. Griniasty, M. Okada, M. Okada, M. Okada, M. Shiino, M. Shiino, M.F. Eckenhoff, M.P. Stryker, M.V. Tsodyks, Masato Okada, P. Rakic, P.R. Huttenlocker, P.R. Huttenlocker, S. Amari, T. Kimoto, Tomoyuki Kimoto   +31 more
core   +1 more source

Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse [PDF]

, 2019
In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs ...
Elgoyhen, Ana Belen, Katz, Eleonora, Kearney, Graciela Inés, Vattino, Lucas Gabriel, Wedemeyer, Carolina, Zorrilla de San Martín, Javier   +5 more
core   +1 more source

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Nature Neuroscience, 2019
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remain a key open question ...
Georgia Gunner, Lucas Cheadle, Kasey M. Johnson, Pinar Ayata, Ana Badimon, Erica Mondo, Aurel Nagy, Liwang Liu, S. Bemiller, Ki-Wook Kim, S. Lira, B. Lamb, A. Tapper, R. Ransohoff, M. Greenberg, A. Schaefer, D. Schafer   +16 more
semanticscholar   +1 more source

Synaptic Release Potentiation at Aging Auditory Ribbon Synapses

Frontiers in Aging Neuroscience, 2021
Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses.
Thibault Peineau, Thibault Peineau, Séverin Belleudy, Susanna Pietropaolo, Yohan Bouleau, Yohan Bouleau, Didier Dulon, Didier Dulon   +7 more
doaj   +1 more source

Glycobiology of the synapse [PDF]

Glycobiology, 2002
Synapses are the fundamental units of connectivity that link together the nervous system. Lectin studies from 30 years ago suggested that specific glycans are concentrated at neuromuscular synapses in the peripheral nervous system and at excitatory synapses in the brain.
openaire   +3 more sources

An Oxide Schottky Junction Artificial Optoelectronic Synapse.

ACS Nano, 2019
The rapid development of artificial intelligence techniques and future advanced robot systems sparks emergent demand on the accurate perception and understanding of the external environments via visual sensing systems that can co-locate the self-adaptive
Shuang Gao, Gang Liu, Huali Yang, Chao Hu, Qilai Chen, Guodong Gong, Wuhong Xue, Xiaohui Yi, J. Shang, Run‐Wei Li   +9 more
semanticscholar   +1 more source

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

Haematologica, 2013
Anticoagulation by a standard dosage of an inhibitor of thrombin generation presupposes predictable pharmacokinetics and pharmacodynamics of the anticoagulant.
Saartje Bloemen, H. Coenraad Hemker, Raed Al Dieri   +2 more
doaj   +1 more source