Results 31 to 40 of about 466,973 (293)
The Immunological Synapse [PDF]
Cancer Immunology Research, 2003 AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Nature Communications, 2017 Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to be the result ...
L. Weinhard +11 more
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SynEM, automated synapse detection for connectomics
eLife, 2017 Nerve tissue contains a high density of chemical synapses, about 1 per µm3 in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the
Benedikt Staffler +5 more
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The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy
Frontiers in Molecular Neuroscience, 2022 Epilepsy is a common symptom of many neurological disorders and can lead to neuronal damage that plays a major role in seizure-related disability.
Yuwen Chen +10 more
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Homogeneous Spiking Neuromorphic System for Real-World Pattern Recognition [PDF]
, 2015 A neuromorphic chip that combines CMOS analog spiking neurons and memristive synapses offers a promising solution to brain-inspired computing, as it can provide massive neural network parallelism and density.
Saxena, Vishal, Wu, Xinyu, Zhu, Kehan
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Glycobiology of the synapse [PDF]
Glycobiology, 2002 Synapses are the fundamental units of connectivity that link together the nervous system. Lectin studies from 30 years ago suggested that specific glycans are concentrated at neuromuscular synapses in the peripheral nervous system and at excitatory synapses in the brain.
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Drosophila gustatory projections are segregated by taste modality and connectivity
eLife, 2022 Gustatory sensory neurons detect caloric and harmful compounds in potential food and convey this information to the brain to inform feeding decisions. To examine the signals that gustatory neurons transmit and receive, we reconstructed gustatory axons ...
Stefanie Engert +3 more
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A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
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Recent Progress in Photonic Synapses for Neuromorphic Systems
Advanced Intelligent Systems, 2020 Implementing synaptic functions with electronic devices is critical to achieve neuromorphic systems on the hardware platform, as synapses play important roles in brain computing and memory.
Junyao Zhang +4 more
semanticscholar +1 more source
RNA, 2015 One reason we learn and remember is because synapses, the places where axons and dendrites meet, undergo experience-dependent changes whose long-lasting nature may underlie the formation and persistence of memory. Indeed, neurons use these morphological and biochemical alterations to distinguish experienced (i.e., stimulated) from naive (unstimulated ...
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