Results 41 to 50 of about 445,271 (401)

SynEM, automated synapse detection for connectomics

eLife, 2017
Nerve tissue contains a high density of chemical synapses, about 1 per µm3 in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the
Benedikt Staffler, Manuel Berning, Kevin M Boergens, Anjali Gour, Patrick van der Smagt, Moritz Helmstaedter   +5 more
doaj   +1 more source

Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2020
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease ...
Catarina Perdigão, Mariana A. Barata, Margarida N. Araújo, Farzaneh S. Mirfakhar, Jorge Castanheira, Cláudia Guimas Almeida   +5 more
doaj   +1 more source

Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

Cells, 2021
The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. Recent studies revealed that in addition to dopaminergic and serotoninergic neuromodulatory systems, microglia also ...
Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityatev   +6 more
doaj   +1 more source

Recycling at synapses

eLife, 2016
Synaptic vesicles in rodent neurons are recycled using at least two distinct mechanisms.
Henrique von Gersdorff, Owen P Gross
openaire   +4 more sources

Aberrant Synaptic Pruning in CNS Diseases: A Critical Player in HIV-Associated Neurological Dysfunction?

Cells, 2022
Even in the era of effective antiretroviral therapies, people living with Human Immunodeficiency Virus (HIV) are burdened with debilitating neurological dysfunction, such as HIV-associated neurocognitive disorders (HAND) and HIV-associated pain, for ...
Zachary Watson, Shao-Jun Tang
doaj   +1 more source

Recent Progress in Photonic Synapses for Neuromorphic Systems

Advanced Intelligent Systems, 2020
Implementing synaptic functions with electronic devices is critical to achieve neuromorphic systems on the hardware platform, as synapses play important roles in brain computing and memory.
Junyao Zhang, Shilei Dai, Yiwei Zhao, Jianhua Zhang, Jia Huang   +4 more
semanticscholar   +1 more source

Microglia shape presynaptic properties at developing glutamatergic synapses [PDF]

, 2019
Deficient neuron-microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly defined.
Arnoux, Bollinger, Cantaut-Belarif, Constantine-Paton, Conti, De Biase, Dobrunz, Doorn, Dumas, Durand, Durand, Gasparini, Gosselin, Grabert, Hellwig, Hessler, Hoshiko, Hsia, Isaac, Khazipov, Korber, Kullmann, Lam, Lavin, Limatola, Lowery, Maggi, Milior, Miyamoto, Mosser, Nimmerjahn, Pagani, Paolicelli, Paolicelli, Parkhurst, Pascual, Pfeiffer, Piccinin, Ragozzino, Renger, Reshef, Reshef, Ricci-Tersenghi, Sallert, Santello, Schafer, Schecter, Sellner, Semple, Singh, Stevens, Tian, Tremblay, Tremblay, Voronin, Wake, Wasling, Weinhard, Winkler, Wolf, Yoon, Zhan   +61 more
core   +1 more source

Dark microglia: Why are they dark?

Communicative & Integrative Biology, 2016
Using transmission electron microscopy (TEM) we recently characterized a microglial phenotype that is induced by chronic stress, fractalkine receptor deficiency, aging, or Alzheimer disease pathology.
Kanchan Bisht, Kaushik Sharma, Baptiste Lacoste, Marie-Ève Tremblay   +3 more
doaj   +1 more source

Neurofilament Levels in Dendritic Spines Associate with Synaptic Status

Cells, 2023
Neurofilaments are one of the main cytoskeletal components in neurons; they can be found in the form of oligomers at pre- and postsynapses. How their presence is regulated at the postsynapse remains largely unclear.
Clara-Marie Gürth, Maria Augusta do Rego Barros Fernandes Lima, Victor Macarrón Palacios, Angel Rafael Cereceda Delgado, Jasmine Hubrich, Elisa D’Este   +5 more
doaj   +1 more source

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

bioRxiv, 2019
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes.
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, S. Ha, Nicholas J. Luciano, Cory M Willis, G. Gao, S. Crocker, B. Popko, D. Reich, D. Schafer   +10 more
semanticscholar   +1 more source