Results 201 to 210 of about 571,868 (347)

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat HippocampusIn Vivo [PDF]

, 2001
Joung‐Hun Kim, Roger Anwyl, Yoo‐Hun Suh, Mustafa B.A. Djamgoz, Michael J. Rowan   +4 more
openalex   +1 more source

Neuropeptide-mediated synaptic plasticity regulates context-dependent mating behaviors in Drosophila. [PDF]

PLoS Biol
Zhang T, Wu Z, Song Y, Ryu TH, Zhang X, Li W, Sun Y, Wong K, Schweizer J, Nguyen KH, Kwan A, Yu K, Kim WJ.   +12 more
europepmc   +1 more source

Advanced Biomaterial Delivery of Hypoxia‐Conditioned Extracellular Vesicles (EVs) as a Therapeutic Platform for Traumatic Brain Injury

Advanced Science, EarlyView.
This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein, Songzi Zhang, Eun Ji Roh, Jeffrey Luo, Meizi Chen, Hyunjun Jang, Li Ling Goldston, Brandon Conklin, Inbo Han, Ki‐Bum Lee   +9 more
wiley   +1 more source

Neurotrophins and synaptic plasticity in the mammalian spinal cord [PDF]

, 2001
Lorne M. Mendell, John B. Munson, Victor L. Arvanian   +2 more
openalex   +1 more source

The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticity. [PDF]

Sci Signal
Chanda K, Grinman E, Clark K, Sadhu A, Raveendra B, Swarnkar S, Puthanveettil SV.   +6 more
europepmc   +1 more source

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

Advanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie, Yiling Peng, Tianyu Qin, Cuimei Chen, Zhenxiao Ren, Naibo Feng, Chungeng Liu, Songlin Peng, Houqing Long   +8 more
wiley   +1 more source

Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway [PDF]

, 2001
Ruifen Bi, Michael R. Foy, Rose‐Marie Vouimba, Richard F. Thompson, Michel Baudry   +4 more
openalex   +1 more source

Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period. [PDF]

PLoS Biol
Sobrido-Cameán D, Coulson B, Miller M, Oswald MCW, Pettini T, Bailey DMD, Baines RA, Landgraf M.   +7 more
europepmc   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source