Results 221 to 230 of about 169,161 (276)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca²⁺-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function. [PDF]

Front Physiol
Cannata B, Sposito L, Albini M, Aceto G, Puliatti G, Lazzarino G, Ripoli C, Tropea MR, Puzzo D, Piacentini R, Grassi C.   +10 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

The impact of diffusion on receptor binding during synaptic transmission. [PDF]

Biophys J
Jackson MB.
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

GABA_AR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation. [PDF]

Transl Psychiatry
Tong J, Gao J, Qi Y, Gao Z, Wang Q, Liu Y, Yuan T, Ren M, Yang G, Li Z, Li J, Sun H, Zhao X, Leung YY, Mu Y, Xu J, Lu C, Peng S, Ge L.   +18 more
europepmc   +1 more source

Bidirectional Photoadaptive Organic Heterojunction Synaptic Transistors for Accurate Image Recognition in Machine Vision Systems

Advanced Science, EarlyView.
Bidirectional photoadaptive organic synaptic phototransistors are developed using complementary n–n and n‐p heterojunctions. These devices enable intelligent in‐sensor processing, markedly enhancing image contrast and edge features under adverse lighting, and achieve a recognition accuracy of 97.4% within ten training cycles for machine vision ...
Di Xue, Hongyu Liu, Yingying Zhang, Feng Ding, Jie Lu, Yao Yin, Zi Wang, Jianlong Xu, Lifeng Chi, Lizhen Huang   +9 more
wiley   +1 more source

Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing. [PDF]

J Neurosci
Thomas RE, Mudlaff F, Schweers K, Farmer WT, Suvrathan A.   +4 more
europepmc   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, EarlyView.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source