Results 231 to 240 of about 1,906,626 (299)

Hypoactivity, abnormal development of dendrites relevant to impaired synaptic transmission of calretinin-expressing interneurons in the medial prefrontal cortex underlies social deficits of mouse model in autism. [PDF]

Transl Psychiatry
Chen M, Zhao K, Gao C, Mei D, Shi S, Wang L, Sun L, Guo J, Bin G, Zhao S, Yan X, He M, Zhang Y, Wang X.   +13 more
europepmc   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Neuron-glioma synaptic transmission amplified by free 19S proteasome-mediated AMPAR deubiquitination promotes tumor progression. [PDF]

Neurotherapeutics
Lu Y, Liu X, Wang K, Wang Z, Shen L, Yuan S, Zhang Z, Qian J.   +7 more
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission. [PDF]

Nat Commun
White KI, Khan YA, Qiu K, Balaji A, Couoh-Cardel S, Esquivies L, Pfuetzner RA, Diao J, Brunger AT.   +8 more
europepmc   +1 more source

Excitatory Synaptic Transmission Is Differentially Modulated by Opioid Receptors along the Claustrocingulate Pathway. [PDF]

eNeuro
Reeves JM, Arias-Hervert E, Kmiec GE, Birdsong WT.   +3 more
europepmc   +1 more source

Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells. [PDF]

Nat Commun
Daphne D, Ahire A, Singh SP, Wagner S, Barkai E, Reuveni I.   +5 more
europepmc   +1 more source

Synaptic transmission: Munc13 assembles onto PI(4,5)P₂-rich domains into trimers that cooperate to capture vesicles. [PDF]

Proc Natl Acad Sci U S A
Li F, Radhakrishnan A, Gautam S, Diaz G, Sundaram RVK, Coleman J, Zheng H, Grushin K, Chavent M, Rothman JE, Pincet F.   +10 more
europepmc   +1 more source

Conditional mGluR5 knockout in glutamatergic pathways disrupts the development of excitatory synaptic transmission onto mouse MNTB neurons. [PDF]

J Neurophysiol
Wang H, Alquraish D, Yu X, Wang Y, Lu Y.
europepmc   +1 more source

Circular RNAs as a novel player in synaptic transmission and neuropsychiatric disorders. [PDF]

Neuropsychopharmacology
Olcay A.
europepmc   +1 more source