Results 71 to 80 of about 304,453 (323)

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation?

Advanced Biology, EarlyView.
The article explores the discovery of unusually large, ring‐shaped ESCRT protein structures formed by immune and stromal cells. It investigates their formation, composition, and potential roles in immune synapse formation. The findings challenge assumptions about their function in immunological synapses, suggesting an exclusive role in maintaining ...
Anthi Psoma, Femmy C. Stempels, Rinse de Boer, Geert van den Bogaart   +3 more
wiley   +1 more source

Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network

Frontiers in Cellular Neuroscience, 2018
Selective pressure may drive neural systems to process as much information as possible with the lowest energy cost. Recent experiment evidence revealed that the ratio between synaptic excitation and inhibition (E/I) in local cortex is generally ...
Lianchun Yu, Lianchun Yu, Zhou Shen, Chen Wang, Yuguo Yu   +4 more
doaj   +1 more source

Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons

, 2003
The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity.
A. Artola, B.L. Sabatini, C. Racca, C.E. Jahr, D.E. Feldman, D.E. Feldman, G. Bi, G. Carmignoto, G.C. Castellani, Gastone C. Castellani, H. Markram, H. Markram, H.D. Abarbanel, H.Z. Shouval, H.Z. Shouval, Harel Z. Shouval, J.A. Cummings, J.A. Lisman, J.C. Magee, Luk C. Yeung, M. Nishiyama, M.E. Larkum, M.F. Bear, M.F. Bear, N. Levy, P.J. Sjöström, R. Kempter, S. Song, S.M. Dudek, S.N. Yang, T. Kitajima, T.V.P. Bliss, U.R. Karmarkar, V.N. Murthy, W. Senn   +34 more
core   +1 more source

Neuromorphic Learning towards Nano Second Precision [PDF]

, 2013
Temporal coding is one approach to representing information in spiking neural networks. An example of its application is the location of sounds by barn owls that requires especially precise temporal coding. Dependent upon the azimuthal angle, the arrival
Meier, Karlheinz, Pfeil, Thomas, Schemmel, Johannes, Scherzer, Anne-Christine   +3 more
core   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood

Frontiers in Cellular Neuroscience, 2020
One of the risk factors for schizophrenia is maternal infection. We have previously shown that Polyriboinosinic-polyribocytidylic acid (poly I:C) induced maternal immune activation in mice caused histological changes in the hippocampal CA1 area of ...
Keiju Nakagawa, Hiroki Yoshino, Yoichi Ogawa, Kazuhiko Yamamuro, Sohei Kimoto, Yoshinobu Noriyama, Manabu Makinodan, Masayuki Yamashita, Yasuhiko Saito, Toshifumi Kishimoto   +9 more
doaj   +1 more source

Enhanced Switching Performance in Single‐Crystalline PbTiO3 Ferroelectric Memristors for Replicating Synaptic Plasticity

Advanced Functional Materials, EarlyView.
This study demonstrated single‐crystalline PbTiO3‐based memristors with atomically sharp interfaces, well‐ordered lattices, and minimal lattice mismatch. The devices exhibited an ON/OFF ratio exceeding 105, high stability, and rich resistance‐state modulation.
Haining Li, Zhiqiang Liao, Risa Kataoka, Md Sarker Shamim, Takeshi Kijima, Hiroyasu Yamahara, Hitoshi Tabata, Munetoshi Seki   +7 more
wiley   +1 more source

Model-Based Inference of Synaptic Transmission

Frontiers in Synaptic Neuroscience, 2019
Synaptic computation is believed to underlie many forms of animal behavior. A correct identification of synaptic transmission properties is thus crucial for a better understanding of how the brain processes information, stores memories and learns ...
Ola Bykowska, Camille Gontier, Anne-Lene Sax, David W. Jia, Milton Llera Montero, Milton Llera Montero, Alex D. Bird, Alex D. Bird, Conor Houghton, Jean-Pascal Pfister, Jean-Pascal Pfister, Rui Ponte Costa, Rui Ponte Costa   +12 more
doaj   +1 more source

The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines [PDF]

, 2004
The number of receptors opening after glutamate release is critical for understanding the sources of noise and the dynamic range of synaptic transmission.
Nimchinsky, E. A., Oertner, T. G., Svoboda, K., Yasuda, R.   +3 more
core   +1 more source