Results 71 to 80 of about 2,697,657 (391)

Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+ channel peptides [PDF]

, 2011
: Modulation of presynaptic voltage-dependent Ca+ channels is a major means of controlling neurotransmitter release. The CaV 2.2 Ca2+ channel subunit contains several inhibitory interaction sites for Gβγ subunits, including the amino terminal (NT) and I ...
Agler, Agler, Altier, Bean, Cantí, Catterall, Chaplan, De Waard, De Waard, Dolphin, Drummond, Ertel, Gary J. Stephens, Giovanna Bucci, Herlitze, Herlitze, Herlitze, Hille, Hümmer, Ikeda, Ikeda, Jones, Kajikawa, Lee, Li, Ma, Matthews, Meir, Mochida, Mochida, Mochida, Opatowsky, Page, Page, Page, Qin, Raghib, Richards, Simen, Simen, Stephens, Stephens, Stephens, Stephens, Stephens, Suh, Sumiko Mochida, Tedford, Tedford, Van Petegem, Williams, Yang, Zamponi, Zhang   +53 more
core   +2 more sources

Synaptic transmission parallels neuromodulation in a central food-intake circuit

bioRxiv, 2016
NeuromedinU is a potent regulator of food intake and activity in mammals. In Drosophila, neurons producing the homologous neuropeptide hugin regulate feeding and locomotion in a similar manner.
P. Schlegel, M. Texada, Anton Miroschnikow, Andreas Schoofs, Sebastian Hückesfeld, M. Peters, Casey M. Schneider-Mizell, Haluk Lacin, Feng Li, R. Fetter, J. Truman, Albert Cardona, M. Pankratz   +12 more
semanticscholar   +1 more source

Capsaicin Enhances Glutamatergic Synaptic Transmission to Neonatal Rat Hypoglossal Motor Neurons via a TRPV1-Independent Mechanism

Frontiers in Cellular Neuroscience, 2017
We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors.
Prajwal P. Thakre, Mark C. Bellingham
doaj   +1 more source

Contribution of Membrane Lipids to Postsynaptic Protein Organization

Frontiers in Synaptic Neuroscience, 2021
The precise subsynaptic organization of proteins at the postsynaptic membrane controls synaptic transmission. In particular, postsynaptic receptor complexes are concentrated in distinct membrane nanodomains to optimize synaptic signaling.
Manon Westra, Yolanda Gutierrez, Harold D. MacGillavry   +2 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

Nature Communications, 2016
Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism for synaptic plasticity. In the brain, AMPARs assemble with a number of auxiliary subunits, including TARPs, CNIHs and CKAMP44, which are important for AMPAR forward ...
X. Gu, Xia Mao, Marc P. Lussier, M. A. Hutchison, Liang Zhou, F. Kent Hamra, Katherine W. Roche, W. Lu   +7 more
semanticscholar   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

Frontiers in Computational Neuroscience, 2009
Inter-pyramidal synaptic connections are characterized by a wide range of EPSP amplitudes. Although repeatedly observed at different brain regions and across layers, little is known about the synaptic characteristics that contribute to this wide range ...
Alex Loebel, Gilad Silberberg, Daniela Helbig, Henry Markram, Misha Tsodyks, Magnus Richardson   +5 more
doaj   +1 more source

Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability in an Animal Model of Multiple Sclerosis [PDF]

International Neurourology Journal, 2016
Purpose: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It has been shown that memory deficits is common in patients with MS.
Ghasem Mosayebi, Mohammad Reza Soleyman, Mostafa khalili, Masoumeh Mosleh, Mohammad Reza Palizvan   +4 more
doaj   +1 more source

Oscillations in Spurious States of the Associative Memory Model with Synaptic Depression [PDF]

, 2014
The associative memory model is a typical neural network model, which can store discretely distributed fixed-point attractors as memory patterns. When the network stores the memory patterns extensively, however, the model has other attractors besides the memory patterns. These attractors are called spurious memories.
arxiv   +1 more source