Results 121 to 130 of about 125,336 (300)

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Synaptic Transmission: An Information-Theoretic Perspective [PDF]

, 1998
Here we analyze synaptic transmission from an information-theoretic perspective. We derive closed-form expressions for the lower-bounds on the capacity of a simple model of a cortical synapse under two explicit coding paradigms.
Koch, C., Manwani, A.
core   +2 more sources

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

npj Parkinson's Disease
Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies (DLB), but whether αS influences synaptic vesicle dynamics in human cortical neurons
Andrew J. White, Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young-Pearse, Ulf Dettmer, Dennis J. Selkoe, Gary P. H. Ho   +7 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Modeling the Contributions of the Exocytotic Machinery and Receptor Desensitization to Short- and Long-Term Plasticity of Synapses Between Neocortical Pyramidal Neurons [PDF]

, 2001
Short-term synaptic depression (STD) refers to the progressive decrease in synaptic efficacy during a spike train. This decrease may be explained in terms of presynaptic and postsynaptic processes, such as a decrease in the probability of transmitter ...
Cohen, Michael, Okatan, Murat
core   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Brain‐Adhesive Bioelectronics With Shape‐Morphable and Biodegradable Properties for Stable Brain Signal Monitoring

Advanced Science, EarlyView.
A brain‐adhesive sensor (B‐Sensor) was developed by integrating a self‐healing biodegradable elastomer, a tissue‐adhesive hydrogel, and molybdenum electrodes. The B‐Sensor adheres to brain tissue, conforms to cortical curvatures, and maintains stable electrical performance over the intended period for reliable recording of spatiotemporal brain activity
Heewon Choi, Soeun Kim, Sumin Kim, Jaehyun Park, Soojung An, Sungjun Yoon, Mikyung Shin, Sangho Cho, Donghee Son   +8 more
wiley   +1 more source

vEMRec: High‐Resolution Volume Electron Microscopy Reconstruction Based on Structure‐Preserving and High‐Fidelity 3D Alignment

Advanced Science, EarlyView.
vEMRec is a frequency‐adaptive computational framework for three‐dimensional alignment in volume electron microscopy. It integrates feature‐based rigid alignment with Gaussian filter‐guided elastic registration to correct rigid misalignments and nonlinear distortions while preserving structural fidelity.
Zhenbang Zhang, Hongjia Li, Zhongjun Yang, Zhiqiang Xu, Duanchen Sun, Xin Gao, Fa Zhang, Renmin Han   +7 more
wiley   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source