Results 101 to 110 of about 634,741 (343)

Actin cage for the synaptic vesicle liquid phase

Cell Reports
Summary: Synaptic vesicles in nerve terminals are organized into a cluster at the active zone, where they fuse with the presynaptic membrane during synaptic activity. This cluster is proposed to be organized as a liquid phase dependent on synapsin. Using
Lennart Brodin, Oleg Shupliakov
doaj   +1 more source

Synaptic Vesicle Dynamics sans Dynamin [PDF]

Neuron, 2007
The neuron-specific guanosine triphosphatase dynamin 1 has been hypothesized to be critically required for pinching off synaptic vesicles during endocytosis. In a recent publication in Science, Ferguson et al. describe a series of experiments demonstrating an unexpectedly selective requirement of dynamin 1 in synaptic vesicle endocytosis only during ...
openaire   +4 more sources

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. [PDF]

, 2014
The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear ...
Antonios, Joseph K, Bushong, Eric A, Ellisman, Mark H, Ghosh, Anirvan, Koo, Edward H, Raam, Tara, Wilke, Scott A   +6 more
core   +3 more sources

Synaptic vesicle recycling: steps and principles

EMBO Journal, 2014
Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear.
S. Rizzoli
semanticscholar   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity

, 2012
In this paper we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and ...
Majumdar, Kaushik, Tewari, Shivendra
core   +1 more source

Sharing vesicles between central presynaptic terminals: implications for synaptic function

Frontiers in Synaptic Neuroscience, 2010
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance.
Kevin Staras, Tiago Branco, Tiago Branco
doaj   +1 more source

Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation

Molecular Biology of the Cell, 2014
This is the first study to show the direct effects of α-synuclein on synaptic vesicle trafficking and to elucidate the underlying structural mechanisms. Acutely increasing α-synuclein severely inhibits synaptic vesicle recycling from the plasma membrane.
David J. Busch, P. Oliphint, Rylie B. Walsh, Susan M. L. Banks, Wendy S. Woods, J. George, J. Morgan   +6 more
semanticscholar   +1 more source

Recycling of Synaptic Vesicles

, 1997
Publisher Summary A widely accepted model describes the synaptic vesicle cycle as a modification of the receptor-mediated recycling pathway present in all cells. This pathway, by which cell surface receptors, like transferrin or low-density lipoprotein receptors, are internalized and recycled back to the surface, involves two distinct vesicular ...
R, Bauerfeind, C, David, D, Grabs, P S, McPherson, Y, Nemoto, V I, Slepnev, K, Takei, P, De Camilli   +7 more
openaire   +2 more sources