Results 121 to 130 of about 297,963 (299)
Synaptic vesicle organization, tethers and connectors.
, 2018 (A) Synaptic vesicle distribution in respect to the plasma membrane for individual nonsynaptic boutons. (B) Synaptic vesicle tethers (black arrowheads) and connectors involving tethered vesicles (white arrowheads) in nonsynaptic boutons. (C) Histogram of
Dimitri Vanhecke (84546) +7 more
core +1 more source
Activity-dependence of synaptic vesicle dynamics [PDF]
, 2017 The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Klyachko, Vitaly A. +8 more
core +1 more source
Advanced Science, EarlyView.A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang +7 more
wiley +1 more source
npj Parkinson's DiseaseAlpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies (DLB), but whether αS influences synaptic vesicle dynamics in human cortical neurons
Andrew J. White +7 more
doaj +1 more source
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source
Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy
Advanced Science, EarlyView.ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin +8 more
wiley +1 more source
Advanced Science, EarlyView.This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh +2 more
wiley +1 more source
Synaptic vesicle recycling in preclinical models of intellectual disability, autism spectrum disorder and epilepsy [PDF]
, 2018 The development of the central nervous system is dysregulated in neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, and epilepsy.
Bonnycastle, Katherine
core +2 more sources
Advanced Science, EarlyView.A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang +17 more
wiley +1 more source
The Synaptic Vesicle/Indentation Complex.
, 2014 Panel A shows a lateral view of an indentation with three rods associated with its wall (yellow) and one protruding into the cytoplasm (cyan). Panel B is a top view of the plasma membrane (Ppre) indicating that a complex arrangement of rods at the ...
Raul Serrano (588202) +2 more
core +1 more source