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Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal Positron Emission Tomography-Magnetic Resonance Imaging Study. [PDF]

Biol Psychiatry
Asch RH, Fan S, Cool R, Boster S, DellaGioia N, Naganawa M, Nabulsi N, Lacadie C, Pietrzak RH, Esterlis I.   +9 more
europepmc   +1 more source

Temporal and Spatial Changes in Synaptic Vesicle Glycoprotein 2A (SV2A) Under Kainic Acid Induced Epileptogenesis: An Autoradiographic Study [PDF]

Epilepsy Research, 2022
Synaptic Vesicle Glycoprotein 2A (SV2A) has been proposed as a presynaptic marker in several neurological disorders. Not only is SV2A the target for the antiepileptic drug levetiracetam, but also considered a marker of mature pre-synapses. In this study, we aimed to assess the binding of [3H]UCB-J as a selective radioligand for SV2A to visualize and ...
Jens Damsgaard Mikkelsen, Eser Öz Oyar, Cansu B Eğilmez   +2 more
exaly   +6 more sources

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Therapeutic Role of Synaptic Vesicle Glycoprotein 2A (SV2A) in Modulating Epileptogenesis

CNS and Neurological Disorders - Drug Targets, 2017
Dysfunction of synaptic neurotransmitter release is closely involved in the pathogenesis of various central nervous system diseases. Synaptic vesicle glycoprotein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles and it modulates action potential-dependent neurotransmitter release in the brain.
Yukihiro Ohno
exaly   +3 more sources

Enabling efficient PET imaging of Synaptic Vesicle glycoprotein 2A (SV2A) with a robust and one-step radiosynthesis of a highly potent 18F-labelled ligand ([18F]UCB-H)

2016
We herein describe the straightforward synthesis of a stable pyridyl(4- methoxyphenyl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radiosynthesis of [18F]UCB-H ([18F]7), a PET tracer for the imaging of Synaptic Vesicle glycoprotein 2A (SV2A).
Warnier, Corentin, Lemaire, Christian, Becker, Guillaume, Zaragoza, Guillermo, Giacomelli, Fabrice, Aerts, Joël, Otabashi, Muhammad, Bahri, Mohamed Ali, Mercier, Joël, Plenevaux, Alain, Luxen, André   +10 more
openaire   +1 more source

111. Synaptic Vesicle Glycoprotein 2A (SV2A) Levels as a Translatable Measure of Synaptic Density Following HDAC Inhibition

Biological Psychiatry, 2018
Magnus Ivarsson, Maria Quinton, Berkley Lynch, Timothy McKee, Nathan Fuller, Adam Rosenberg   +5 more
openaire   +1 more source

P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE

Alzheimer's & Dementia, 2018
Ming-Kai Chen, Adam P. Mecca, Mika Naganawa, Sjoerd J. Finnema, Takuya Toyonaga, Jean-Dominique Gallezot, Julia W. McDonald, Hannah R. Michalak, Nabeel B. Nabulsi, Yiyun Huang, Amy F.T. Arnsten, Richard E. Carson, Christopher H. van Dyck   +12 more
openaire   +1 more source

IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE

Alzheimer's & Dementia, 2018
Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Sjoerd J. Finnema, Takuya Toyonaga, Shu-fei Lin, Jean-Dominique Gallezot, Julia W. McDonald, Hannah R. Michalak, Nabeel B. Nabulsi, Yiyun Huang, Amy F.T. Arnsten, Richard E. Carson, Christopher H. van Dyck   +13 more
openaire   +1 more source