Stress and synaptic density in psychosis and clinical high risk: evidence from [18F]SynVesT-1 PET [PDF]
Translational PsychiatrySynaptic dysfunction is implicated in the pathophysiology of schizophrenia, and positron emission tomography (PET) studies demonstrate in vivo reductions in synaptic density across illness stages.
M. Belen Blasco +9 more
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Effects of Subanesthetic Intravenous Ketamine Infusion on Stress Hormones and Synaptic Density in Rats with Mild Closed-Head Injury [PDF]
BiomedicinesBackground: Every year, over 40 million people sustain mild traumatic brain injury (mTBI) which affects the glucocorticoid stress pathway and synaptic plasticity.
Martin Boese +6 more
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Synaptic density in aging mice measured by [18F]SynVesT-1 PET
NeuroImage, 2023 Synaptic alterations in certain brain structures are related to cognitive decline in neurodegeneration and in aging. Synaptic loss in many neurodegenerative diseases can be visualized by positron emission tomography (PET) imaging of synaptic vesicle ...
Mengfei Xiong +7 more
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Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study [PDF]
Alzheimer’s Research & TherapyBackground The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD).
Elaheh Salardini +7 more
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Lower synaptic density is associated with depression severity and network alterations
Nature Communications, 2019 Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is ...
Sophie E. Holmes +14 more
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Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder [PDF]
General PsychiatryBackground Understanding synaptic alteration in obsessive-compulsive disorder (OCD) is crucial for elucidating its pathological mechanisms, but in vivo research on this topic remains limited.Aims This study aimed to identify the synaptic density ...
Ming Zhou +6 more
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Frontiers in Radiology, 2022 The gut microbiome profoundly influences brain structure and function. The gut microbiome is hypothesized to play a key role in the etiopathogenesis of neuropsychiatric and neurodegenerative illness; however, the contribution of an intact gut microbiome ...
Sue Y. Yi +16 more
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Frontiers in Psychiatry, 2023 BackgroundKetamine and psychedelics have abuse liability. They can also induce “transformative experiences” where individuals experience enhanced states of awareness.
Simon Zhornitsky +18 more
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Imaging Synaptic Density: The Next Holy Grail of Neuroscience?
Frontiers in Neuroscience, 2022 The brain is the central and most complex organ in the nervous system, comprising billions of neurons that constantly communicate through trillions of connections called synapses.
Maria Elisa Serrano +8 more
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Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
Frontiers in Neurology, 2021 Background: Gray matter pathology plays a central role in the progression of multiple sclerosis (MS). The occurrence of synaptic loss appears to be important but, to date, still poorly investigated aspect of MS pathology.
E. E. Amelie Möck +5 more
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