Pre-synaptic terminal dynamics in the hippocampus [PDF]
, 2003 This thesis work dealt with the study of synaptic plasticity in the adult brain. This is an area of intensive investigation because instability of synapses is believed to underlie cognitive processes like learning and memory in the CNS, and adaptation ...
De Paola, Vincenzo
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Neurobiology of Stress, 2023 Maternal infection during pregnancy and childhood social trauma have been associated with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum disorders, bipolar disorder and depression.
Cyprien G.J. Guerrin +7 more
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APOE ε4 is associated with decreased synaptic density in cognitively impaired participants. [PDF]
Alzheimers DementHe K +15 more
europepmc +2 more sources
Modulation of behavior by scaffolding proteins of the post-synaptic density [PDF]
Neurobiology of Learning and Memory, 2013 Scaffolding proteins of the neuronal post-synaptic density (PSD) are principal organizers of glutamatergic neurotransmission that bring together glutamate receptors and signaling molecules at discrete synaptic locations. Genetic alterations of individual PSD scaffolds therefore disrupt the function of entire multiprotein modules rather than a single ...
Can, Gao +2 more
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Frontiers in Aging Neuroscience, 2021 Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear underlying mechanism.
Yanyan Kong +13 more
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Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling [PDF]
, 2014 The spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires ...
Pachoud, B +9 more
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Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures [PDF]
, 2012 Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (≥3 weeks old) mouse organotypic entorhino-hippocampal slice cultures.
Roeper, Jochen +23 more
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Learning to Discriminate Through Long-Term Changes of Dynamical Synaptic Transmission [PDF]
, 2008 Short-term synaptic plasticity is modulated by long-term synaptic changes. There is, however, no general agreement on the computational role of this interaction.
Gundlfinger, Anja +10 more
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Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease. [PDF]
Alzheimers DementINTRODUCTION: Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated associations between SV2A
Mecca AP +23 more
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Frontiers in Molecular NeuroscienceObjectiveStudies on feeling of ear fullness (FEF) related to sudden sensorineural hearing loss(SSNHL) are limited. The mechanisms of FEF are unclear. This study aimed to explore the characteristics and related brain activation of SSNHL with FEF.MethodsA ...
En Zhou +4 more
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