Results 11 to 20 of about 2,928,945 (285)

Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration [PDF]

Nature Communications, 2023
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models ...
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe   +16 more
doaj   +16 more sources

The Rise of Synaptic Density PET Imaging [PDF]

Molecules, 2020
Many neurological disorders are related to synaptic loss or pathologies. Before the boom of positrons emission tomography (PET) imaging of synapses, synaptic quantification could only be achieved in vitro on brain samples after autopsy or surgical ...
Guillaume Becker, Sylvestre Dammicco, Mohamed Ali Bahri, Eric Salmon   +3 more
doaj   +3 more sources

Imaging synaptic density in depression [PDF]

Neuropsychopharmacology, 2022
Major depressive disorder is a prevalent and heterogeneous disorder with treatment resistance in at least 50% of individuals. Most of the initial studies focused on the monoamine system; however, recently other mechanisms have come under investigation. Specific to the current issue, studies show synaptic involvement in depression.
Sophie E. Holmes, Chadi Abdallah, Irina Esterlis   +2 more
openaire   +3 more sources

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels [PDF]

Cell Reports, 2016
Synaptic ribbons are structures made largely of the protein Ribeye that hold synaptic vesicles near release sites in non-spiking cells in some sensory systems. Here, we introduce frameshift mutations in the two zebrafish genes encoding for Ribeye and thus remove Ribeye protein from neuromast hair cells. Despite Ribeye depletion, vesicles collect around
Caixia Lv, William J. Stewart, Otar Akanyeti, Courtney Frederick, Jie Zhu, Joseph Santos-Sacchi, Lavinia Sheets, James C. Liao, David Zenisek   +8 more
openaire   +4 more sources

Synaptic density in carriers of C9orf72 mutations: a [11C]UCB‐J PET study [PDF]

Annals of Clinical and Translational Neurology, 2021
Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [11C]UCB‐J PET to quantify synaptic density in comparison with 19 ...
Maura Malpetti, Negin Holland, P. Simon Jones, Rong Ye, Thomas E. Cope, Tim D. Fryer, Young T. Hong, George Savulich, Timothy Rittman, Luca Passamonti, Elijah Mak, Franklin I. Aigbirhio, John T. O’Brien, James B. Rowe   +13 more
doaj   +6 more sources

Presynaptic active zone density during development and synaptic plasticity [PDF]

Frontiers in Molecular Neuroscience, 2012
Neural circuits transmit information through synapses, and the efficiency of synaptic transmission is closely related to the density of presynaptic active zones, where synaptic vesicles are released. The goal of this review is to highlight recent insights into the molecular mechanisms that control the number of active zones per presynaptic terminal ...
Clarke, Gwenaëlle L., Chen, Jie, Nishimune, Hiroshi   +2 more
openaire   +5 more sources

Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia. [PDF]

Int J Mol Sci
Schizophrenia is a highly polygenic disease, and several genetic variants associated with the disease converge on altered synaptic homeostasis. In particular, the gene encoding complement component 4 (C4) showed the strongest association with schizophrenia, and this protein is involved in complement-dependent and microglia-mediated synaptic pruning. As
Sapienza J, Spangaro M, Comai S, Sabé M, La Torre J, Buonarroti M, Cavallaro R, Bosia M.   +7 more
europepmc   +3 more sources

The glutamate post-synaptic density in schizophrenia [PDF]

, 2012
Non-competitive antagonists of the glutamate N-methyl-D-aspartate receptor (NMDAR) induce a broad range of schizophrenia-like symptoms in humans.
Matas, Emmanuel
core   +4 more sources

Imaging of Synaptic Density in Neurodegenerative Disorders

Journal of Nuclear Medicine, 2022
PET technology has produced many radiopharmaceuticals that target specific brain proteins and other measures of brain function. Recently, a new approach has emerged to image synaptic density by targeting the synaptic vesicle protein 2A (SV2A), an integral glycoprotein in the membrane of synaptic vesicles and widely distributed throughout the brain ...
Carson, Richard E., Naganawa, Mika, Toyonaga, Takuya, Koohsari, Sheida, Yang, Yanghong, Chen, Ming-Kai, Matuskey, David, Finnema, Sjoerd J.   +7 more
openaire   +2 more sources

Twelve-Week Yoga vs. Aerobic Cycling Initiation in Sedentary Healthy Subjects: A Behavioral and Multiparametric Interventional PET/MR Study

Frontiers in Psychiatry, 2021
Interventional yoga studies with an active control group remain scarce and are important to clarify the underlying neurobiology. We conducted an interventional study in healthy controls using simultaneous positron emission tomography/magnetic resonance ...
June van Aalst, Lise Jennen, Koen Demyttenaere, Koen Demyttenaere, Stefan Sunaert, Stefan Sunaert, Michel Koole, Jenny Ceccarini, Koen Van Laere, Koen Van Laere   +9 more
doaj   +1 more source