Results 21 to 30 of about 2,928,945 (285)

Cerebrospinal fluid and brain PET measures of synaptic density glycoprotein 2A: Biomarkers of synaptic density in Alzheimer’s disease [PDF]

Alzheimer's & Dementia, 2021
AbstractBackgroundSynaptic loss is linked with Alzheimer’s disease (AD) progression and provides a novel target for exploration with fluid and imaging biomarkers. Studies using [11C]UCB‐J–PET have shown significant reductions in synaptic glycoprotein 2A (SV2A) specific binding as a marker of synaptic density in early AD.
Adam P. Mecca, Nicholas J. Ashton, Ming‐Kai Chen, Ryan S. O'Dell, Mika Naganawa, Takuya Toyonaga, Wenzhen Zhao, Nabeel B. Nabulsi, Ann Brinkmalm, Hlin Kvartsberg, Michael Schöll, Amy F.T. Arnsten, Yiyun Huang, Kaj Blennow, Henrik Zetterberg, Richard E. Carson, Christopher H. van Dyck, Johanna Nilsson   +17 more
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Novel Brain Synaptic Density Nuclide Molecular Probe 18F-SynVesT-1 Radiolabeling, Quality Control and Imaging Analysis

Journal of Isotopes, 2023
Neural synapses were the fundamental sites of interneuronal connections and the structural basis for information transmission in brain networks, and alterations in synapse density were closely related to a variety of nervous system disorders.
HU Zhengquan;XIANG Shijun;TANG Yongxiang;CHEN Dengming;HU Shuo
doaj   +1 more source

Gender differences in human cortical synaptic density [PDF]

Proceedings of the National Academy of Sciences, 2008
Certain cognitive functions differ in men and women, although the anatomical and functional substrates underlying these differences remain unknown. Because neocortical activity is directly related with higher brain function, numerous studies have focused on the cerebral cortex when searching for possible structural correlates of cognitive gender ...
Alonso-Nanclares, Lidia, González-Soriano, Juncal, Rodríguez Sánchez, José Rodrigo, DeFelipe, Javier   +3 more
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Synaptic Vesicle Glycoprotein 2A: Features and Functions

Frontiers in Neuroscience, 2022
In recent years, the field of neuroimaging dramatically moved forward by means of the expeditious development of specific radioligands of novel targets.
Rachele Rossi, Rachele Rossi, Shokouh Arjmand, Simone Larsen Bærentzen, Simone Larsen Bærentzen, Albert Gjedde, Albert Gjedde, Albert Gjedde, Anne M. Landau, Anne M. Landau   +9 more
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Ultrastructural effects of monocular deprivation in the neuropil of nucleus rotundus in the zebra finch: a quantitative electron microscopic study [PDF]

, 1987
Nixdorf B, Bischof H-J. Ultrastructural effects of monocular deprivation in the neuropil of nucleus rotundus in the zebra finch: a quantitative electron microscopic study. Brain Research.
Nixdorf, Barbara, Bischof, Hans-Joachim
core   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Todorov, Boyan, Furukawa, Keiko, Furukawa, K., Plomp, J.J., Verschuuren, Jan J., Willison, H.J., Furukawa, Koichi, Plomp, Jaap J., Jacobs, B.C., Todorov, B., Willison, Hugh J., Jacobs, Bart C., Zitman, F.M.P., Verschuuren, J.J., Zitman, Femke M.P.   +14 more
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Structural Insights Into the Dynamic Evolution of Neuronal Networks as Synaptic Density Decreases

Frontiers in Neuroscience, 2019
The human brain is thought to be an extremely complex but efficient computing engine, processing vast amounts of information from a changing world. The decline in the synaptic density of neuronal networks is one of the most important characteristics of ...
Ye Yuan, Ye Yuan, Jian Liu, Jian Liu, Peng Zhao, Peng Zhao, Fu Xing, Fu Xing, Hong Huo, Hong Huo, Tao Fang, Tao Fang   +11 more
doaj   +1 more source

Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET study

Frontiers in Human Neuroscience, 2023
Introduction: Resting-state network (RSN) connectivity is a widely used measure of the brain’s functional organization in health and disease; however, little is known regarding the underlying neurophysiology of RSNs.
Xiaotian T. Fang, Tommaso Volpi, Sophie E. Holmes, Irina Esterlis, Irina Esterlis, Richard E. Carson, Patrick D. Worhunsky   +6 more
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SynapCountJ: A Tool for Analyzing Synaptic Densities in Neurons

Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies, 2016
The quantification of synapses is instrumental to measure the evolution of synaptic densities of neurons under the effect of some physiological conditions, neuronal diseases or even drug treatments. However, the manual quantification of synapses is a tedious, error-prone, time-consuming and subjective task; therefore, tools that might automate this ...
Mata, G. [0000-0002-5567-8463], Heras, J. [0000-0003-4775-1306], Morales, M., Romero, A. [0000-0001-9745-417X], Rubio, J. [0000-0002-4282-3692]   +4 more
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Reduced Synapse and Axon Numbers in the Prefrontal Cortex of Rats Subjected to a Chronic Stress Model for Depression

Frontiers in Cellular Neuroscience, 2018
Stressful experiences can induce structural changes in neurons of the limbic system. These cellular changes contribute to the development of stress-induced psychopathologies like depressive disorders.
Dávid Csabai, Ove Wiborg, Ove Wiborg, Boldizsár Czéh, Boldizsár Czéh   +4 more
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