Results 41 to 50 of about 2,928,945 (285)

Neuroanatomical Abnormalities in Behaviorally Characterized APPV717F Transgenic Mice

Neurobiology of Disease, 2000
Histological analyses were performed on the brains of APPV717F transgenic (Tg)mice previously studied in a battery of behavioral tests. We describe here the regional and age-dependent deposition of amyloid in both heterozygous and homozygous Tg mice.
Jean-Cosme Dodart, Chantal Mathis, Josep Saura, Kelly R. Bales, Steven M. Paul, Arielle Ungerer   +5 more
doaj   +1 more source

Presynaptically silent synapses are modulated by the density of surrounding astrocytes

Journal of Pharmacological Sciences, 2020
Astrocytes, comprising the primary glial-cell type, are involved in the formation and maturation of synapses, and thus contribute to sustainable synaptic transmission between neurons.
Kohei Oyabu, Kotomi Takeda, Hiroyuki Kawano, Kaori Kubota, Takuya Watanabe, N. Charles Harata, Shutaro Katsurabayashi, Katsunori Iwasaki   +7 more
doaj   +1 more source

Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease

Frontiers in Molecular Neuroscience, 2023
Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the huntingtin gene, which encodes the mutant huntingtin protein containing an ...
Chen Xu, Sidong Chen, Xingxiang Chen, Ka Hei Ho, Chungwon Park, Chungwon Park, Hanna Yoo, Suk-Ho Lee, Hyokeun Park, Hyokeun Park, Hyokeun Park   +10 more
doaj   +1 more source

Plasma pTau217, gender, and synaptic density [PDF]

Alzheimers Dement
AbstractBackgroundSynaptic loss is a key feature of Alzheimer’s disease (AD) dementia. In the entorhinal cortex (ERC) and hippocampus, phosphorylated tau (pTau) colocalizes with synaptosomes, and its presence may play a role in AD‐related synaptic loss. However, the relationship between pTau and synaptic density is not well understood.
Yang K, DiFilippo A, Ma Y, Wilson R, Thor Y, Pasquesi M, Barnhart T, Engle J, Betthauser T, Ashton N, Johnson S, Christian B, Zetterberg H, Bendlin B.   +13 more
europepmc   +2 more sources

PET imaging of synaptic density in Parkinsonian disorders

Journal of Neuroscience Research, 2023
Abstract Synaptic dysfunction and altered synaptic pruning are present in people with Parkinsonian disorders. Dopamine loss and alpha‐synuclein accumulation, two hallmarks of Parkinson's disease (PD) pathology, contribute to synaptic dysfunction and reduced synaptic density in PD.
Sarah L. Martin, Carme Uribe, Antonio P. Strafella   +2 more
openaire   +2 more sources

Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]

, 2011
Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Koch, Sabine, Cooper, Jonathan D, Svetlana M. Molchanova, Taira, Tomi, Tyynelä, Jaana, Jonathan D. Cooper, Ann K. Wright, Thomas H. Gillingwater, Sabine Koch, Andrew Edwards, Wright, Ann K, Gillingwater, Thomas H, Molchanova, Svetlana M, Jaana Tyynelä, Edwards, Andrew, Tomi Taira   +15 more
core   +1 more source

Invariant synaptic density across species

Abstract The nervous system scales with animal size while preserving function, yet the principles underlying this stability remain unclear. Here, we analyse the ultra-structure and connectivity of thousands of neuronal cells across species, including fly, zebrafish, mouse, and human, and found a conserved feature that stabilises ...
Ferreira Castro A, Cardona A.
europepmc   +2 more sources

MSK1 regulates homeostatic and experience-dependent synaptic plasticity [PDF]

, 2012
The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response ...
Frenguelli, BrunoG., Corrêa, SAL, McKenzie, Colin, Palygin, O, Palygin, Oleg, Martin, KJ, Arthur, J.S., McKelvey, Kim, Hunter, CJ, Morris, R. G. M. (Richard G. M.), Morris, R.G., Morris, RGM, McKenzie, C, Hunter, Christopher J., Wauters, Sandrine C., Pankratov, Yuriy, Hunter, C.J., Wauters, S.C., Wauters, SC, Wauters, Sandrine, Martin, K.J., Arthur, J.Simon C.; id_orcid, Palygin, O., Frenguelli, BG, Corrêa, Sonia A.L., Corrêa, Sônia A. L., Arthur, J. Simon C., Frenguelli, Bruno G., Morris, Richard G. M., Frenguelli, B.G., Pankratov, Y., Martin, Kirsty J., McKelvey, Kim M. (Kim Martin), McKenzie, C., Arthur, JSC, McKelvey, K., Pankratov, Y, McKelvey, K   +37 more
core   +1 more source

The influence of synaptic size on AMPA receptor activation: a Monte Carlo model. [PDF]

PLoS ONE, 2015
Physiological and electron microscope studies have shown that synapses are functionally and morphologically heterogeneous and that variations in size of synaptic junctions are related to characteristics such as release probability and density of ...
Jesus Montes, Jose M Peña, Javier DeFelipe, Oscar Herreras, Angel Merchan-Perez   +4 more
doaj   +1 more source

Differentiation of dendrites and the analysis of spine- like structures on Lobula Plate Tangential Cells in Drosophila melanogaster [PDF]

, 2007
The development of dendrites leads to the establishment of cell-type specific morphology of dendritic trees that eventually determines the way in which synaptic information is processed within the nervous system. The aim of this study was to investigate
Koper, Ewa
core   +1 more source