Results 61 to 70 of about 2,928,945 (285)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Synaptic state matching: a dynamical architecture for predictive internal representation and feature perception [PDF]

, 2011
Here we consider the possibility that a fundamental function of sensory cortex is the generation of an internal simulation of sensory environment in real-time.
Saeed Tavazoie (7618), Tavazoie Saeed, Saeed Tavazoie, Tavazoie, Saeed   +3 more
core   +2 more sources

Three-dimensional vertical structural electrochemical random access memory for high-density integrated synapse device

Scientific Reports, 2023
Three-terminal (3T) structured electrochemical random access memory (ECRAM) has been proposed as a synaptic device based on improved synaptic characteristics.
Hyejin Kim, Jongseon Seo, Seojin Cho, Seonuk Jeon, Jiyong Woo, Daeseok Lee   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]

, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J., Martina Kurejova, Thomas Kuner, Irmgard Tegeder (179372), Hu, S.J., Kurejova Martina, Bali, K.K., Agarwal, Nitin, Anke Tappe-Theodor, Bali, Kiran Kumar, Polgar Erika, Franz Hofmann (179398), Todd, A.J., Lewin, G., Kuner Thomas, Ceng Luo (179354), Feil, Robert, Jens Schlossmann, Polgar, E., Gangadharan Vijayan, Andrew J Todd, Kurejova, Martina, Feil, Susanne, Ceng Luo, Hu, S., Susanne Feil (179376), Andrew J. Todd (179384), Feil, R., Rohini Kuner (179428), Erika Polgar (5649442), Rohini Kuner, Hu, San-Jue, Liu Da-Lu, Liu, D., Kuner, Thomas, San-Jue Hu (179417), Feil, S., Tegeder, Irmgard, Tappe-Theodor Anke, Kuner, R., Nitin Agarwal (179363), Robert Feil (28669), Agarwal, N., Agarwal Nitin, Xie, R.G., Robert Feil, Kiran Kumar Bali (179358), Da-Lu Liu (179408), Erika Polgar, Kuner, T., Tappe, Anke, Gary Lewin (179380), Liu, Da-Lu, Xie, R. G., Jens Schlossmann (179389), Nitin Agarwal, Luo, Ceng, Luo, C., Vijayan Gangadharan, Hu, S. J., Xie, Rou-Gang, Hofmann Franz, Da-Lu Liu, Rou-Gang Xie (179362), Bali Kiran Kumar, Tappe-Theodor, A., Kuner, Rohini, Lewin Gary, Liu, D. L., Kiran Kumar Bali, Irmgard Tegeder, Polgár, Erika, Hofmann, Franz, Tegeder Irmgard, Vijayan Gangadharan (179356), Rou-Gang Xie, Schlossmann Jens, Franz Hofmann, Feil Susanne, Hu San-Jue, San-Jue Hu, Xie Rou-Gang, Gangadharan, Vijayan, Todd Andrew J., Feil Robert, Martina Kurejova (179365), Bali, K. K., Gary Lewin, Susanne Feil, Anke Tappe-Theodor (179367), Lewin, Gary R., Schlossmann, Jens, Liu, D.L., Thomas Kuner (162293), Schlossmann, J., Luo Ceng, Gangadharan, V., Hofmann, F., Kuner Rohini, Todd, Andrew J., Xie, R., Tegeder, I., Kurejova, M., Luo, C;Gangadharan, V;Bali, KK;Xie, RG;Agarwal, N;Kurejova, M;Tappe-Theodor, A;Tegeder, I;Feil, S;Lewin, G;Polgar, E;Todd, AJ;Schlossmann, J;Hofmann, F;Liu, DL;Hu, SJ;Feil, R;Kuner, T;Kuner, R   +103 more
core   +2 more sources

Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

eLife, 2019
PDZ domain scaffold proteins are molecular modules orchestrating cellular signalling in space and time. Here, we investigate assembly of PDZ scaffolds using supported cell membrane sheets, a unique experimental setup enabling direct access to the ...
Simon Erlendsson, Thor Seneca Thorsen, Georges Vauquelin, Ina Ammendrup-Johnsen, Volker Wirth, Karen L Martinez, Kaare Teilum, Ulrik Gether, Kenneth Lindegaard Madsen   +8 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Posthatching development of synapses in the neuropil of nucleus rotundus of the zebra finch: a quantitative electron microscopic study [PDF]

, 1986
Nixdorf B, Bischof H-J. Posthatching development of synapses in the neuropil of nucleus rotundus of the zebra finch: a quantitative electron microscopic study. The Journal of Comparative Neurology.
Nixdorf, Barbara, Barbara Nixdorf, Hans‐Joachim Bischof, Bischof, Hans-Joachim   +3 more
core   +1 more source

Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy

Fundamental Research
Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions. Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused researchers to shift their focus to ...
Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding   +3 more
doaj   +1 more source