Results 81 to 90 of about 2,928,945 (285)

A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction [PDF]

, 2008
Background: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Fox Michael A, Ho Matthew SP, Fox, Michael, Sanes Joshua R, Sanes, Joshua R, Ho, Matthew S. P., Smyth, Neil, Sanes, Joshua, Smyth Neil, Fox, Michael A., Sanes, Joshua R., Ho, Matthew S.P., Ho, Matthew SP, Michael A Fox, Matthew SP Ho, Neil Smyth, Joshua R Sanes   +16 more
core   +1 more source

Viral modulation of synaptic pruning: implications for neuropathology and brain function

Journal of Virology
Synaptic pruning is an essential neurodevelopmental process that refines neural circuits by eliminating superfluous or weak synapses, thereby enhancing cognitive functions, including learning and memory.
Shayan Aliakbari, Sareh Asadi, Mohammad Sayyah, Nima Naderi, Shakiba Salarvandian, Fariba Khodagholi, Hamid Gholami Pourbadie   +6 more
doaj   +1 more source

Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain

Acta Neuropathologica Communications, 2023
Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood.
Wenzhang Wang, Fanpeng Zhao, Yubing Lu, Sandra L. Siedlak, Hisashi Fujioka, Hao Feng, George Perry, Xiongwei Zhu   +7 more
doaj   +1 more source

SynapCountJ: A Validated Tool for Analyzing Synaptic Densities in Neurons

, 2017
The quantification of synapses is instrumental to measure the evolution of synaptic densities of neurons under the effect of some physiological conditions, neuronal diseases or even drug treatments. However, the manual quantification of synapses is a tedious, error-prone, time-consuming and subjective task; therefore, reliable tools that might automate
Gadea Mata, Germán Cuesto, Jónathan Heras, Miguel Morales, Ana Romero 0001, Julio Rubio 0001   +5 more
openaire   +2 more sources

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Dose reduction for synaptic density PET imaging in Parkinson’s disease

NeuroImage
Objective: Dynamic PET imaging with 11C-UCB-J enables in vivo quantification of synaptic vesicle glycoprotein 2A (SV2A), with prior reports of lower synaptic density in areas such as the brainstem nuclei and substantia nigra (SN) in Parkinson’s disease ...
Andi Li, Mika Naganawa, Praveen Honhar, Kathryn Fontaine, Paul Gravel, David Matuskey, Richard E. Carson, Jing Tang   +7 more
doaj   +1 more source

Total Number of Synapses in the Adult Human Neocortex

Undergraduate Journal of Mathematical Modeling: One + Two, 2010
The brain is composed of glial cells and neurons where synapses form connections between neurons and other cells. Since synapses are very small, so either a light or electron microscope is required to see them. Unlike other mammals, synapses in the human
Thai Nguyen
doaj   +1 more source

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source