Results 201 to 210 of about 29,089 (240)
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Science, 2005
The mechanisms underlying exo- and endocytosis of neurotransmitter vesicles at synaptic terminals are still not fully understood. Although many endocytic pathways have been documented, there is little direct evidence on the molecular dependence of endocytosis. Yamashita et al.
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The mechanisms underlying exo- and endocytosis of neurotransmitter vesicles at synaptic terminals are still not fully understood. Although many endocytic pathways have been documented, there is little direct evidence on the molecular dependence of endocytosis. Yamashita et al.
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Modes and mechanisms of synaptic vesicle recycling
Current Opinion in Neurobiology, 2016Neurotransmission requires the recycling of synaptic vesicles (SVs) to replenish the SV pool, clear release sites, and maintain presynaptic integrity. In spite of decades of research the modes and mechanisms of SV recycling remain controversial. The identification of clathrin-independent modes of SV recycling such as ultrafast endocytosis has added to ...
Tolga Soykan +2 more
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Synaptic vesicle recycling in synaptosomes in vitro
Nature, 1976PINCHED-OFF presynaptic nerve terminals (synaptosomes) prepared from rat brain homogenates1,2 retain many of the functional properties of intact neurones3,4. They can accumulate K+ and extrude Na+ against concentration gradients5,6, and their membranes seem to develop K+ diffusion potentials which behave like the membrane potentials of most neurones7 ...
R C, Fried, M P, Blaustein
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Synaptic vesicle recycling intermediates revealed
BioEssays, 1995AbstractNeurotransmitter release takes place by the exocytosis of loaded synaptic vesicles. The vesicles then fuse to the presynaptic membrane and are recycled by an endocytotic mechanism. A quantitative optical assay that detects uptake and release of a fluorescent dye during presynaptic activity was recently developed and used on the frog ...
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Synaptic vesicle endocytosis and recycling
1999Abstract ‘The yang having reached its climax retreats in favor of the yin; the yin having reached its climax retreats in favor of the yang.’ -Wang Chu’ung (AD 80) on Tai Chi Tu Exocytosis and endocytosis, the yin and yang elements of the vesicle cycle, must be well balanced to ensure continuous synaptic transmission.
Bing Zhang, Mani Ramaswami
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Ultrafast recycling of synaptic vesicles
The FASEB Journal, 2017Neurons can fire at extremely high rates. To sustain neurotransmission, synaptic vesicles must be recycled locally at synapses. Two models for synaptic vesicle endocytosis have been put forward based on the morphological studies in frog neuromuscular junctions.
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Retrograde regulation of synaptic vesicle endocytosis and recycling
Nature Neuroscience, 2003Sustained release of neurotransmitter depends upon the recycling of synaptic vesicles. Until now, it has been assumed that vesicle recycling is regulated by signals from the presynaptic bouton alone, but results from rat hippocampal neurons reported here indicate that this need not be the case.
Kristina D, Micheva +3 more
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Calcium Source Alters Synaptic Vesicle Recycling
Science's STKE, 2002Two pools of synaptic vesicles are identifiable in synapses: the readily releasable pool (the so-called ECP) that is located at the periphery of the neuron that undergoes rapid exocytosis and endocytosis upon depolarization, and the reserve pool (RP) that is located more centrally and that is released upon high-frequency tetanic ...
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Phosphorylation of dynamin I and synaptic-vesicle recycling
Trends in Neurosciences, 1994In nerve terminals, neurotransmitters are packaged in synaptic vesicles, and released by exocytosis. Empty synaptic vesicles are rapidly recycled for reuse by endocytosis. Much progress has been made in identifying the proteins involved in synaptic-vesicle trafficking, but the mechanism and regulation of endocytosis have largely remained an enigma. One
P J, Robinson +4 more
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Synaptic Vesicle Recycling: Genetic and Cell Biological Studies
Journal of Neurogenetics, 2010We review mainly the work from our research group here. Our focus has been on the use of genetic methods to delineate the mechanisms of synaptic vesicle recycling and cellular trafficking. Acute temperature-sensitive paralytic mutants have been of particular value in this approach. We have primarily used screens for suppressor and enhancer mutations to
Riddhi, Majumder, K S, Krishnan
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