Results 141 to 150 of about 549,591 (370)

Scattering synaptic vesicles [PDF]

The Journal of Cell Biology, 2006
![][1] The BDNF-induced increase (left) in synapses (red) on a neuron (green) is lost if β-catenin and cadherin are locked together (right). Synaptic vesicles get dispersed to new sites, according to Bamji et al.
openaire   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Enhanced Synaptic Transmission at the Squid Giant Synapse by Artificial Seawater Based on Physically Modified Saline

Frontiers in Synaptic Neuroscience, 2014
Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission.
Soonwook eChoi, Soonwook eChoi, Eunah eYu, Eunah eYu, Guilherme eRabello, Guilherme eRabello, Suelen eMerlo, Ajmal eZemmar, Kerry D Walton, Kerry D Walton, Herman eMoreno, Herman eMoreno, Jorge E Moreira, Jorge E Moreira, Mutsuyuki eSugimori, Mutsuyuki eSugimori, Rodolfo R Llinas, Rodolfo R Llinas   +17 more
doaj   +1 more source

Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles [PDF]

, 2018
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher ...
Bewick, Guy Smith, Lomo, T., Martinov, V. N., Nja, A., Reid, Brian   +4 more
core   +1 more source

The Vesicular GABA Transporter, VGAT, Localizes to Synaptic Vesicles in Sets of Glycinergic as Well as GABAergic Neurons

Journal of Neuroscience, 1998
A transporter thought to mediate accumulation of GABA into synaptic vesicles has recently been cloned (McIntire et al., 1997). This vesicular GABA transporter (VGAT), the first vesicular amino acid transporter to be molecularly identified, differs in ...
F. Chaudhry, R. Reimer, Elizabeth E. Bellocchio, N. Danbolt, K. Osen, R. Edwards, J. Storm-Mathisen   +6 more
semanticscholar   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Presynaptic molecular determinants of quantal size

Frontiers in Synaptic Neuroscience, 2016
The quantal hypothesis for the release of neurotransmitters at the chemical synapse has gained wide acceptance since it was first worked out at the motor endplate in frog skeletal muscle in the 1950s.
Shigeo eTakamori
doaj   +1 more source

Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]

, 2017
The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia, Dardis, Andrea, DE STEFANO, Maria Egle, Dragotto, Jessica, Erickson, Robert P., Fiorenza, Maria Teresa, Mangia, Franco, Zampieri, Stefania   +7 more
core   +1 more source

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

Journal of Neuroscience, 1995
Whether amphetamine acts principally at the plasma membrane or at synaptic vesicles is controversial. We find that d-amphetamine injection into the Planorbis giant dopamine neuron causes robust dopamine release, demonstrating that specific amphetamine ...
David SuIzer, T. Chen, Y. Lau, H. Kristensen, S. Rayport, Andrew Ewing   +5 more
semanticscholar   +1 more source

vEMINR: Ultra‐Fast Isotropic Reconstruction for Volume Electron Microscopy With Implicit Neural Representation

Advanced Science, EarlyView.
vEMINR is an ultra‐fast isotropic reconstruction method for vEM based on implicit neural representation, achieving over tenfold faster reconstruction and higher accuracy on 11 datasets, showing strong potential for large‐scale vEM data processing.
Jibin Yang, Jie Huo, Muyu Liu, Chenjie Feng, Yan Zhang, Gang Pan, Wenjia Meng, Renmin Han   +7 more
wiley   +1 more source