Results 161 to 170 of about 354,036 (296)

Transient docking of synaptic vesicles: Implications and mechanisms. [PDF]

Curr Opin Neurobiol, 2022
Kusick GF, Ogunmowo TH, Watanabe S.
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

The missing link: Piccolino is essential for tethering synaptic vesicles to rod photoreceptor ribbons. [PDF]

J Cell Biol
Gierke K, Gadomska M, Breuer J, Bahr JN, Müller TM, Ehnis H, Zobel S, Mejia Villagran N, Kirsch SA, Skrzypek A, Frischknecht R, Fejtová A, Böckmann RA, Wichmann C, Regus-Leidig H, Brandstätter JH.   +15 more
europepmc   +1 more source

Prioritized docking of synaptic vesicles provided by a rapid recycling pathway. [PDF]

iScience, 2023
Tran V, Silva M, Marty A.
europepmc   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Turbocharging synaptic transmission: 12 SNAREpins are required for rapid release of reconstituted synaptic vesicles. [PDF]

Sci Adv
Bera M, Chatterjee A, Aji AK, Panda A, Sundaram RVK, Coleman J, Maroofian R, Salpietro V, Radhakrishnan A, Gautam S, Grushin K, Caruel M, Houlden H, Gupta K, Ramakrishnan S, Pincet F, Rothman JE.   +16 more
europepmc   +1 more source

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles. [PDF]

Elife, 2023
Mueller BD, Merrill SA, Watanabe S, Liu P, Niu L, Singh A, Maldonado-Catala P, Cherry A, Rich MS, Silva M, Maricq AV, Wang ZW, Jorgensen EM.   +12 more
europepmc   +1 more source

Hyperactive KIF5A in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos, James N. Sleigh   +1 more
wiley   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Multimodal imaging of synaptic vesicles with a single probe. [PDF]

Cell Rep Methods, 2022
An SJ, Stagi M, Gould TJ, Wu Y, Mlodzianoski M, Rivera-Molina F, Toomre D, Strittmatter SM, De Camilli P, Bewersdorf J, Zenisek D.   +10 more
europepmc   +1 more source