Results 171 to 180 of about 74,688 (303)

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization. [PDF]

EMBO J
Chhabra A, Hoffmann C, Aguilar Pérez G, Korobeinikov AA, Rentsch J, Hümpfer N, Kokwaro L, Gnidovec L, Petrović A, Wallace JN, Tromm JV, Román-Vendrell C, Johnson EC, Ranković B, Perego E, Volpi T, Fernández-Busnadiego R, Köster S, Rizzoli SO, Ewers H, Morgan JR, Milovanović D.   +21 more
europepmc   +1 more source

Visualizing Presynaptic Active Zones and Synaptic Vesicles. [PDF]

Front Synaptic Neurosci, 2022
Heckmann M, Pauli M.
europepmc   +1 more source

Rest‐activity patterns across development in two mouse models of autism and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Sleep disturbances are common in individuals with autism spectrum disorder (ASD) and epilepsy and are increasingly recognized as comorbidities that affect disease severity and quality of life. This study investigated rest‐activity patterns across development in two genetic mouse models relevant to ASD and epilepsy: synapsin 2 (Syn2 ...
Ipsa Dash, Filip Fredlund, Jenny Wickham, My Andersson, Christine T. Ekdahl   +4 more
wiley   +1 more source

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment. [PDF]

Nat Neurosci
Ogunmowo TH, Hoffmann C, Patel C, Pepper R, Wang H, Gowrisankaran S, Idel J, Ho A, Raychaudhuri S, Maher BJ, Cooper BH, Milosevic I, Milovanovic D, Watanabe S.   +13 more
europepmc   +1 more source

Rapid isolation and cryo-EM characterization of synaptic vesicles from mammalian brain. [PDF]

FEBS Open Bio, 2022
Du K, Hu L, Wang P, Xue Y.
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. [PDF]

Nat Commun, 2022
Vettkötter D, Schneider M, Goulden BD, Dill H, Liewald J, Zeiler S, Guldan J, Ateş YA, Watanabe S, Gottschalk A.   +9 more
europepmc   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Biogenesis and reformation of synaptic vesicles. [PDF]

J Physiol
Bolz S, Haucke V.
europepmc   +1 more source