Results 151 to 160 of about 119,730 (299)

Establishment and multifaceted characterization of a graded spinal cord injury model based on graduated impact depth

Animal Models and Experimental Medicine, EarlyView.
We established a graded spinal cord injury (SCI) model based on graduated impact depth, which was subsequently characterized across multiple dimensions, including locomotor function, imaging, histology, and transcriptomic profiles. We further identified transcriptomic changes in graded SCI at different time points postinjury and investigated the ...
Gang Zhou, Yue Hu, Zhimin Li, Shiyuan Han, Yuejia Li, Yongning Li, Jun Gao   +6 more
wiley   +1 more source

Molecular architecture of synaptic vesicles. [PDF]

Proc Natl Acad Sci U S A
Kravčenko U, Ruwolt M, Kroll J, Yushkevich A, Zenkner M, Ruta J, Lotfy R, Wanker EE, Rosenmund C, Liu F, Kudryashev M.   +10 more
europepmc   +2 more sources

Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. [PDF]

Neuron, 2023
Song P, Peng W, Sauve V, Fakih R, Xie Z, Ysselstein D, Krainc T, Wong YC, Mencacci NE, Savas JN, Surmeier DJ, Gehring K, Krainc D.   +12 more
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

A novel mouse model simulating C5 palsy after cervical surgery

Animal Models and Experimental Medicine, EarlyView.
This study establishes a reliable mouse model of permanent C5 palsy (post‐laminectomy complication) via dorsal approach, selectively severing the C5 anterior nerve root while preserving the posterior root through partial C4 and C5 laminectomy. The model successfully replicates clinical C5P features—flaccid shoulder paralysis, electrophysiological ...
Chenpei Xu, Xianghe Wang, Mingjie Zhou, Chuxiang Chen, Tingzheng Jiang, Fei Wang, Kaixiang Yang, Hongli Wang, Su Jiang   +8 more
wiley   +1 more source

Transient docking of synaptic vesicles: Implications and mechanisms. [PDF]

Curr Opin Neurobiol, 2022
Kusick GF, Ogunmowo TH, Watanabe S.
europepmc   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Prioritized docking of synaptic vesicles provided by a rapid recycling pathway. [PDF]

iScience, 2023
Tran V, Silva M, Marty A.
europepmc   +1 more source

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles. [PDF]

Elife, 2023
Mueller BD, Merrill SA, Watanabe S, Liu P, Niu L, Singh A, Maldonado-Catala P, Cherry A, Rich MS, Silva M, Maricq AV, Wang ZW, Jorgensen EM.   +12 more
europepmc   +1 more source

Impaired docking and recycling of synaptic vesicles in inherited lysosomal sphingolipidoses. [PDF]

Cell Commun Signal
Zelada D, Saldivia N, Konjeti A, Samano S, Marshall MS, Rebiai R, Sutter P, Zurawski Z, Simchuk D, Muchiri R, van Breemen R, Shin D, Givogri MI, Crocker SJ, Alford S, Bongarzone ER.   +15 more
europepmc   +1 more source