Results 141 to 150 of about 119,730 (299)
Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle
Advanced Science, EarlyView.Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong +7 more
wiley +1 more source
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, EarlyView.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
Photoresponsive Rotaxanes Switch Lipid Bilayer Neuromorphic Behavior with Light
Advanced Electronic Materials, EarlyView.A rotaxane consisting of a macrocycle ring with two azobenzene units mechanically interlocked onto an amphiphilic axle was incorporated into droplet interface bilayers (DIBs). Photoswitching between the azobenzene configurations on the ring resulted in cycling between memristive and memcapacitive behaviors in lipid bilayers, enabling programmable ...
P.T. Podar +4 more
wiley +1 more source
Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
eLifeNeurotransmission at synapses is mediated by the fusion and subsequent endocytosis of synaptic vesicle membranes. Actin has been suggested to be required for presynaptic endocytosis but the mechanisms that control actin polymerization and its mode of ...
Kristine Oevel +6 more
doaj +1 more source
Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics
Advanced Intelligent Discovery, EarlyView.Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu +11 more
wiley +2 more sources
Adaptor protein-3 produces synaptic vesicles that release phasic dopamine. [PDF]
Proc Natl Acad Sci U S A, 2023 Jain S +10 more
europepmc +1 more source
The 9th International RASopathies Symposium
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel +41 more
wiley +1 more source
Angewandte Chemie, EarlyView.Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo +3 more
wiley +2 more sources
N-glycoproteomics of brain synapses and synaptic vesicles. [PDF]
Cell Rep, 2023 Bradberry MM +4 more
europepmc +1 more source