Results 231 to 240 of about 531,557 (374)

The upside of epilepsy: Theories of an evolutionary paradox

Epilepsia Open, EarlyView.
Abstract The persistence of common, heritable conditions, like epilepsy, that are associated with reduced reproductive fitness is an evolutionary paradox. Endogenous analgesic, anti‐depressant, and inflammatory mechanisms able to repair compromised functions can offer advantages in unexpected crises.
Alyssa Ailion, Christoph Helmstaedter, Annamaria Vezzani, Matthias J. Koepp   +3 more
wiley   +1 more source

Translocation of cytosolic acetylcholine into synaptic vesicles and demonstration of vesicular release.

, 1986
D. M. Michaelson, M. Burstein, Roxana Licht   +2 more
openalex   +1 more source

Nanoplatform‐Enabled Genetic Interventions for Central Nervous System Disorders: Advances in Delivery Strategies and Therapeutic Potential

Advanced Genetics, Volume 6, Issue 2, June 2025.
This review provides a detailed description of gene mutations and epigenetic mechanisms in central nervous system (CNS) disease, strategies for gene therapy, challenges for CNS gene therapy and gene‐drug nanocarriers. This review also summarizes the applications of nanogenetic therapy platforms in CNS diseases (brain tumors, neurodegenerative diseases,
Fuming Liang, Shizhen Cui, Jing Yang, Zhaohui He, Ling Zhu   +4 more
wiley   +1 more source

Functionally distinct evoked and spontaneous neurotransmission operate via a shared pool of synaptic vesicles in viscerosensory afferents. [PDF]

J Physiol
Arnold RA, Peters JH.
europepmc   +1 more source

High-Precision Mapping of Membrane Proteins on Synaptic Vesicles using Spectrally Encoded Super-Resolution Imaging. [PDF]

Angew Chem Int Ed Engl, 2023
Jiang Y, Zhang J, Jung SR, Chen H, Xu S, Chiu DT.   +5 more
europepmc   +1 more source

L-glutamate stimulation of Na+ efflux from brain synaptic membrane vesicles.

, 1981
H. H. Chang, Elias K. Michaelis
openalex   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Morphology and intervesicle distances in condensates of synaptic vesicles and synapsin. [PDF]

Biophys J
Neuhaus C, Alfken J, Frost J, Matthews L, Hoffmann C, Ganzella M, Milovanovic D, Salditt T.   +7 more
europepmc   +1 more source

Automated Detection and Localization of Synaptic Vesicles in Electron Microscopy Images. [PDF]

eNeuro, 2022
Imbrosci B, Schmitz D, Orlando M.
europepmc   +1 more source

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts

Glia, EarlyView.
Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst, Nina Meesters, Tim S. Heistek, Marjo S. van der Knaap, Huibert D. Mansvelder, Rogier Min   +5 more
wiley   +1 more source