Results 241 to 250 of about 354,036 (296)

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source

Engineering In Vitro Models of Skeletal Muscle With Neuromuscular Junctions Using Hierarchical Micro‐Nano Biomaterials: Cooperative Effect of Adhesion Ligand Nanoclustering and Surface Anisotropy

Small, EarlyView.
This study investigates the cooperative effects of adhesive ligand distribution, density, and biomaterial morphology for innervated skeletal muscle tissue engineering. Ligand nanoclusters were created in aligned micropatterns by electrospinning of a RAFT‐synthesized polymer with controlled ligand presentation.
Shirin Nour, Kristy Swiderski, Sahar Salehi, Gordon S. Lynch, Andrea J. O'Connor, Greg G. Qiao, Daniel E. Heath   +6 more
wiley   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

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Isolation of Synaptic Vesicles

Current Protocols in Cell Biology, 2004
AbstractSynaptic vesicles are the most abundant secretory organelle in eukaryotic neural cells. Synaptic vesicles are physically distinct from other membrane‐bound organelles because they are small, spherical, and highly uniform in size with a diameter of about 40 nm.
Branch, Craige, Gloria, Salazar, Victor, Faundez   +2 more
openaire   +2 more sources

Formation of synaptic vesicles

Current Opinion in Cell Biology, 1994
Synaptic vesicles (SVs) are specialized secretory organelles used for the fast and focal signaling between nerve cells. They are small and homogeneous in size (50 nm), and contain non-peptide neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA) and acetylcholine. The exocytosis of SVs occurs at low rates in resting nerve terminals and is
O, Mundigl, P, De Camilli
openaire   +2 more sources

THE SYNAPTIC VESICLE CYCLE

Annual Review of Physiology, 1998
▪ Abstract  The ins and outs of the synaptic vesicle cycle are being examined in increasing detail with diverse investigative tools in a variety of cell types, particularly those with large granules. The cycle begins with the opening of a fusion pore that connects the vesicle lumen to the extracellular fluid.
W J, Betz, J K, Angleson
openaire   +2 more sources

Synaptic Vesicles and Exocytosis

Annual Review of Neuroscience, 1994
Neurons transmit information by releasing neurotransmitters from presynaptic nerve endings, In the resting stage , transmitters are stored in small organelles of uniform size and shape , the synaptic vesicles . When an action potential arrives in the nerve terminal , the membrane depolarizes and voltage-gated Ca2+ channels open .
R, Jahn, T C, Südhof
openaire   +2 more sources

Synaptic vesicle pools

Nature Reviews Neuroscience, 2005
Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundred (whisperers) to nearly a million (shouters).
Silvio O, Rizzoli, William J, Betz
openaire   +2 more sources

Biogenesis of synaptic vesicles

Journal of Cell Science, 1993
ABSTRACT The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins.
R B, Kelly, F, Bonzelius, A, Cleves, L, Clift-O'Grady, E, Grote, G, Herman   +5 more
openaire   +2 more sources

Synaptic Vesicles in the Cochlea

Acta Oto-Laryngologica, 1974
The cochlea is innervated by afferent, efferent and sympathetic neurons. The afferent synapses and the efferent and sympathetic nerve terminals contain transmitter substances within their synaptic vesicles. These transmitters are likely to be chemically different in each of the three cochlear nerve populations.
E, Borg, O, Densert, A, Flock
openaire   +2 more sources