Results 41 to 50 of about 284,832 (240)

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Epigenetics of the Synaptonemal Complex

, 2012
Meiosis is a process composed of two divisions of the germ line cells without an intervenient S phase, thus there is no duplication of DNA between the first and the second meiotic divisions. The first meiotic division begins with the pre-leptotene that is the stage where the DNA replicates and chromosomes prepare to enter the meiotic prophase I in most
Abrahan Hernández-Hernández, Rosario Ortiz Hernádez, Gerardo H. Vázquez-Nin   +2 more
openaire   +4 more sources

Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm

AIMS Genetics, 2018
The Leprecan protein family which includes the prolyl 3-hydroxylase enzymes (P3H1, P3H2, and P3H3), the closely related cartilage-associated protein (CRTAP), and SC65 (Synaptonemal complex 65, aka P3H4, LEPREL4), is involved in the post-translational ...
Sarah M. Zimmerman, Roberta Besio, Melissa E. Heard-Lipsmeyer, Milena Dimori, Patrizio Castagnola, Frances L. Swain, Dana Gaddy, Alan B. Diekman, Roy Morello   +8 more
doaj   +1 more source

Meiotic Chromosome Dynamics in Zebrafish

Frontiers in Cell and Developmental Biology, 2021
Recent studies in zebrafish have revealed key features of meiotic chromosome dynamics, including clustering of telomeres in the bouquet configuration, biogenesis of chromosome axis structures, and the assembly and disassembly of the synaptonemal complex ...
Yukiko Imai, Ivan Olaya, Ivan Olaya, Noriyoshi Sakai, Noriyoshi Sakai, Sean M. Burgess   +5 more
doaj   +1 more source

D2Former: A Fully Complex Dual-Path Dual-Decoder Conformer Network using Joint Complex Masking and Complex Spectral Mapping for Monaural Speech Enhancement [PDF]

arXiv, 2023
Monaural speech enhancement has been widely studied using real networks in the time-frequency (TF) domain. However, the input and the target are naturally complex-valued in the TF domain, a fully complex network is highly desirable for effectively learning the feature representation and modelling the sequence in the complex domain.
arxiv  

Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises

Molecular Ecology Resources, EarlyView.
ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty, Raúl Araya‐Donoso, Avery Paulsen, Avery Williams, Dale F. DeNardo, Kenro Kusumi, Greer A. Dolby   +6 more
wiley   +1 more source

Cayley deformations of compact complex surfaces [PDF]

, 2017
In this article, we consider Cayley deformations of a compact complex surface in a Calabi--Yau four-fold. We will study complex deformations of compact complex submanifolds of Calabi--Yau manifolds with a view to explaining why complex and Cayley deformations of a compact complex surface are the same.
arxiv   +1 more source

Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt‐Dependent NAD+ De Novo Synthesis in Mice

Aging Cell, EarlyView.
In Qprt‐deficient mice, testicular NAD+ levels decline accelerated with age, leading to mitochondrial dysfunction, disrupted DSB repair, impaired meiotic sex chromosome inactivation, and germ cell loss. Nicotinamide riboside (NR) supplementation restores NAD+ levels and alleviates these defects, highlighting the importance of NAD+ de novo synthesis in ...
Yining Xu, Huan Wang, Hui Li, Chenlu Wei, Zhenye Zhu, Yanqing Zhao, Jiajia Zhu, Min Lei, Yingpu Sun, Qingling Yang   +9 more
wiley   +1 more source

Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes

Frontiers in Cell and Developmental Biology, 2021
In meiotic prophase I, homologous chromosomes are bound together by the synaptonemal complex, in which two axial elements are connected by transverse filaments and central element proteins.
Yukiko Imai, Kenji Saito, Kazumasa Takemoto, Fabien Velilla, Toshihiro Kawasaki, Toshihiro Kawasaki, Kei-ichiro Ishiguro, Noriyoshi Sakai, Noriyoshi Sakai   +8 more
doaj   +1 more source

EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice

Andrology, EarlyView.
Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang, Longsheng Zhang, Li Yu, Xinli Zhou, Xu Chen, Yuchuan Zhou, Ningling Wang, Hui Zhu   +7 more
wiley   +1 more source