Results 41 to 50 of about 12,224 (202)

Synaptonemal Complexities and Commonalities [PDF]

Molecular Cell, 2003
Formation of synaptonemal complex and high levels of homologous recombination are the hallmarks of meiotic prophase. The relationship between these two processes has been the subject of intense study for nearly 50 years. Recent findings highlight the differences and commonalities of this relationship in different species.
openaire   +2 more sources

Ultrastructural analysis of chromatin in meiosis I plus II of rye (Secale cereale L.) [PDF]

, 2004
Scanning electron microscopy (SEM) proves to be an appropriate technique for imaging chromatin organization in meiosis I and II of rye (Secale cereale) down to a resolution of a few nanometers.
Herrmann, Reinhold G., Hohmann, U., Wanner, Gerhard, Zoller, J. F.   +3 more
core   +1 more source

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling

Molecular Systems Biology, 2013
Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we ...
Yuval Tabach, Tamar Golan, Abrahan Hernández‐Hernández, Arielle R Messer, Tomoyuki Fukuda, Anna Kouznetsova, Jian‐Guo Liu, Ingrid Lilienthal, Carmit Levy, Gary Ruvkun   +9 more
doaj   +1 more source

Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination [PDF]

, 2015
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism.
Alexandra-Styliani Kalantzi, Bergerat, Bishop, Brown, Brunger, Bugreev, Byung-Ha Oh, Case, Chan, Chen, Chi, Cho, Christopher P. Toseland, Cloud, de Massy, De Vlaminck, de Vries, Emsley, Enomoto, Ferrari, Garcia, Haruta, Hayase, Ho-Chul Shin, Holm, Hyun-Ah Kang, Hyun-Min Kim, Keeney, Keeney, Kokabu, Kuwabara, Lange, Leu, Lu, Lu, Lu, Matteo Dal Peraro, Moktan, Morrison, Neale, Okorokov, Otwinowski, Pettersen, Petukhova, Petukhova, Pezza, Pezza, Phillips, Ploquin, Qiao, Rabitsch, Roeder, Rothenberg, Say, Schwacha, Sheridan, Sheridan, Soding, Stephan Gruber, Terwilliger, Tsai, Tsubouchi, Tsubouchi, Uanschou, van der Heijden, Wright, Zhao   +66 more
core   +3 more sources

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash, Kerr, Gary W., Sarkar, Sourav   +2 more
core   +1 more source

A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]

, 2016
Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core   +3 more sources

ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis

Advanced Science, EarlyView.
A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng, Shaochen Jia, Fei Cao, Cuiping Liu, Heshuang Zhang, Gang Xu, Jixin Zhuang, Yashi Zhang, Can Liu, Yuhang Zhao, Zilin Guo, Xinjie Yuan, Jiaqing Yang, Lei Chu, Bowei Cai, Hu Zhao, Chao Yang   +16 more
wiley   +1 more source

A first genetic portrait of synaptonemal complex variation.

PLoS Genetics, 2019
The synaptonemal complex (SC) is a proteinaceous scaffold required for synapsis and recombination between homologous chromosomes during meiosis. Although the SC has been linked to differences in genome-wide crossover rates, the genetic basis of standing ...
Richard J Wang, Beth L Dumont, Peicheng Jing, Bret A Payseur   +3 more
doaj   +1 more source

Surveillance of cohesin-supported chromosome structure controls meiotic progression

Nature Communications, 2020
Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a ...
Maikel Castellano-Pozo, Sarai Pacheco, Georgios Sioutas, Angel Luis Jaso-Tamame, Marian H. Dore, Mohammad M. Karimi, Enrique Martinez-Perez   +6 more
doaj   +1 more source

Synaptonemal complex components promote centromere pairing in pre-meiotic germ cells. [PDF]

PLoS Genetics, 2013
Mitosis and meiosis are two distinct cell division programs. During mitosis, sister chromatids separate, whereas during the first meiotic division, homologous chromosomes pair and then segregate from each other.
Nicolas Christophorou, Thomas Rubin, Jean-René Huynh   +2 more
doaj   +1 more source